The necessity for combined chemotherapy in multi bacillary leprosy has been recognized for about 1 5 years . I-3 It was however entirely unknown how this combined therapy had to be applied, particularly in respect to the drugs to be given, the frequency of their administration and above all the duration of therapy. We have approached the problem on the basis of results obtained in experimental ...

Two types of chelating fibers containing an imidazoline or thioamide group were prepared through the functionalization of hydrazine-modified polyacrylonitrile fiber by ethylenediamine and through the amination and sulfurization reaction of the hydrazine-modified polyacrylonitrile fiber under appropriate conditions, respectively. It is shown that the reaction temperature, time, and agent concent...

The total synthesis of two key analogues of vancomycin containing single-atom exchanges in the binding pocket (residue 4 amidine and thioamide) are disclosed as well as their peripherally modified (4-chlorobiphenyl)methyl (CBP) derivatives. Their assessment indicates that combined pocket amidine and CBP peripherally modified analogues exhibit a remarkable spectrum of antimicrobial activity (VSS...

The title compound, C10H13NOS, is a second monoclinic polymorph (space group P21/c, Z' = 2) of the previously reported C2/c (Z = 1) polymorph [Tadbuppa & Tiekink (2005 ▸). Z. Kristallogr. New Cryst. Struct. 220, 395-396]. Two independent mol-ecules comprise the asymmetric unit of the new polymorph and each of these exists as a thioamide-thione tautomer. In each molecule, the central CNOS chromo...

Triptycene-based micorporous polymer was functionalized with thioamide moieties via post-polymerization using phosphorus pentasulfide as a thionating agent in the presence of sodium sulfite. Gas adsorption experiments indicate that the modification leads to a reduction in the BET surface area of the polymer, from 1640 m g for the parent TMP to 207 m g on 74% conversion of nitrile to thioamide, ...