Until recently, physician–historians of pediatrics have generally assumed that “pediatrics as a specialized branch of medicine had no real existence before the middle of the nineteenth century.”1 This may be true if we equate pediatrics with professional organizations and specialized children’s hospitals.2,3 But as a body of knowledge and practices addressing the sick child, pediatrics has a mu...

Inhalation of toluene-based products is popular among young adults. It has been shown to have a variety of adverse effects on several organs and systems. Although the heart seems to be a sensitive target organ to toluene, cardiotoxicity has often been ignored, especially in cases of acute toluene abuse, with relatively low concentrations. Thereby, routine cardiac examination and echocardiograph...

Nine male volunteers were exposed to 2H8-toluene (200 mg/m3 for two hours during a workload of 50 W) via inspiratory air with the aid of a breathing valve and mouthpiece. Labelled toluene was used to differentiate between hippuric acid originating from exposure to toluene and hippuric acid normally excreted in urine. The total uptake of toluene was 2.2 (standard deviation (SD) 0.2) mmol, or 50%...

McGrath (2005/this issue) has published a very significant article; it is significant because it examines the substantive issue of construct validity in a simple and informative way, noting the confusions apparent in how constructs and their variables are defined, used, and interpreted within the domain of personality and individual differences. This is a careful, thoughtful, article that quiet...