نتایج جستجو برای: therapy resistance
تعداد نتایج: 996157 فیلتر نتایج به سال:
OBJECTIVE To assess HIV-1 isolate based resistance profiles from extensively pretreated patients and effects of a resistance guided switch of antiretroviral therapy. METHODS In a prospective study phenotypic and genotypic resistance analyses were performed on HIV infected individuals with failure of the current therapy and history of at least three antiretroviral regimens. Antiretroviral ther...
BACKGROUND Understanding the mechanisms of drug resistance can facilitate better management of antiretroviral therapy, helping to prevent transmission and decrease the morbidity and mortality of people living with HIV/AIDS. However, there is little data about transmitted drug resistance and acquired drug resistance for HIV/AIDS patients in Shanghai. METHODS A retrospective cohort study of HIV...
From hygienic and economical point of view, drug therapy and prophylaxy in infectious diseases are of great importance. After the world war II, a reduction in the efficacy of sulfonamide in the treatment of shigellosis was observed and later on it led to a survey on drug resistance and the way of its transmission. The aim of this survey, during which 100 cases of gram-negative bacteria were ide...
Background and purpose: Clindamycin is used in treatment of common infections caused by methicillin-resistant Staphylococcus aureus (MRSA). Constitutive or inducible resistance of clindamycin are important factors in choosing that as an effective antibiotic. The aims of this study were to determine inducible resistance clindamycin and analysis of multiple antibiotic resistance profile in clinic...
Background & Objective: Genus Salmonella has more than 2400 serotypes. The two major groups are S.enterica and S.bongori. Important serotypes are situated in S.enterica group. Antibiotic therapy in salmonellosis is restricted to typhoid fever and acute infections. After the first reporting of resistance in S.Typhimurium DT 104, nowadays, developing of resistance in Salmonella, specially, ESBL p...
BACKGROUND Current guidelines for providing antiretroviral therapy (ART) in South Africa's public sector programme call for switching patients from first-line to second-line treatment upon virologic failure as indicated by two consecutive viral loads above 5000 copies/ml, but without laboratory evidence of viral resistance. We modelled the net cost of adding resistance testing for patients with...
Abstract Given the negative contribution of obesity-associated metabolic disorders to formation cardiovascular complications, adequate blood pressure (BP) control is very important in patients with arterial hypertension (AH) and obesity comorbidity. Objective conduct a comparative assessment between hemodynamic parametersinobese true pseudo-resistant AH. Methods The study included 302 uncontrol...
Background and Objective: The global increase in resistance to antibiotics among clinical isolates of Acinetobacter baumannii is reported from several countries, but its true prevalence in Iran is less known. The objective of this study was determination of the frequency of resistance to different antibiotics among Acinetobacter baumannii isolated from patients in two hospitals in Tehran, Iran,...
Long-term therapy with oral nucleoside/nucleotide analogues (NAs) is a favoured approach to the treatment of patients with chronic hepatitis B (CHB); however, all oral agents currently approved for the treatment of such patients are associated with some risk for drug resistance. This can lead to a rebound in HBV levels and, eventually, progressive liver disease. Combination therapy is one strat...
Identification of drug resistant mutations is important in the management of HIV-1 infected patients. The aim of the current study was to evaluate drug resistance profile of RT gene and assess subtype among HIV-1 circulating strains and intensification of physician’s options for the best therapy. HIV-1 RNA of 25 sampleswas extracted from plasma and RT Nested- PCR was performed and the fin...
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