Background: Although ionizing radiation is a risk factor, it is a therapeutic agent for cancer. Objectives: The protective and defensive effect of L-Carnitine and vitamin E on gastrointestinal tract organs (liver, spleen and intestine) post whole body gamma irradiation exposure. Material and methods: 56 male albino rats, which were divided into four groups (14 rats per group); group (I): Contro...

Melanin is a pigment that determines the skin/hair color and protects human skin from UV rays. The synthesis of melanin complex process regulated by variety enzymes, signaling pathways, transcription factors. Among them, metabolic utilization fatty acids in mitochondria considered one main sources energy. extra oxidase stress produced mitochondrial has thought to be vital factor for pathogenesi...

Azanucleosides, such as 5-azacytidine and decitabine, are DNA demethylating agents used in the treatment of acute myeloid leukemia myelodysplastic syndromes. Researchers continue to explore their utility other hematologic solid tumors. Based on capacity compounds inhibit methyltransferase enzymes important role methylation health disease, it is essential understand molecular changes that azanuc...

Background: Mesenchymal stem cells (MSCs) have been recently received increasing attention for cell-based therapy, especially in regenerative medicine. However, the low survival rate of these cells restricts their therapeutic applications. It is hypothesized that autophagy might play an important role in cellular homeostasis and survival. This study aims to investigate the regenerative potentia...

Enzymes control all metabolic processes in human system from simple digestion of food to highly complex immune response. Physiological reactions occuring in healthy individuals are disturbed when enzymes are deficient or absent. Enzymes are administered for normalizing biological function in certain pathologies. Initially, crude proteolytic enzymes were used for the treatment of gastrointestina...

The accumulation of Abeta (amyloid beta-protein) peptides in the brain is a pathological hallmark of all forms of AD (Alzheimer's disease) and reducing Abeta levels can prevent or reverse cognitive deficits in mouse models of the disease. Abeta is produced continuously and its concentration is determined in part by the activities of several degradative enzymes, including NEP (neprilysin), IDE (...

Compost is a promising source of thermotolerant enzymes for their application in biotechnology. Homologues bacteriophage T4 DNA glycosylase can find pharmaceuticals and perfumery. Five homologues pyrimidine dimers T4, product the denV gene, were found by comparing using DELTA-BLAST algorithm with compost metagenome proteins. Phylogenetic analysis sequences enzyme was carried out Maximum Likelih...

Drug delivery across the blood–brain barrier (BBB) has several challenges, especially toward targeting neurological diseases, due to tight and selective function of BBB. Several structural functional components this contribute restricting drug entry, such as interendothelial junctions (TJs), efflux transporters, drug-metabolizing enzymes, crosstalk between cells neurovascular unit. Among differ...