Interactions between HIV and opioid dependence therapies are known to occur. We sought to determine if such interactions occurred between methadone and elvitegravir boosted with cobicistat (EVG/COBI). We performed a within-subject open-label pharmacokinetic and pharmacodynamic study of 11 HIV-seronegative subjects stabilized on at least 2 weeks of methadone. Subjects underwent baseline and stea...

∗The first versions of this book were written in Fall 2001 and June 2002 at Cornell University, respectively supported by an NSF VIGRE Grant and a Department of Mathematics Grant. The current version was written in 2005 at Franklin W. Olin College of Engineering supported by NSF CCLI DUE-0410517 Grant. Edits were made in 2006 under the same grant. If you wish to use this book, please simply let...

T h e \N TOSTAL irn ival proposal and debate concerning The Obser­ ver w ere the m ajor issues covered at last n ig h t’s Hall P res id en ts’s Council m eeting held in LaFortune S tudent C enter. R obertD riscoll of the M cD erm ott A m usem ent Com pany, Inc. p resen ted a film to fam iliarize the Council m em bers w ith his carn i­ val’s operations and attractions. H e said th a t he had “ w...

Transform coding (TC) is an efficient and effective vector quantization approach where the resulting compact representation can be the basis for a more elaborate hierarchical framework for sub-linear approximate search. However, as compared to the state-of-the-art product quantization methods, there is a significant performance gap in terms of matching accuracy. One of the main shortcomings of ...

Objectives This analysis aims at determining how many OTCs were reimbursed before the exclusion and how many of them and under what conditions of reimbursement remained to be reimbursed. The second objective of the analysis is to estimate the financial effect of exclusion on the payers and patients. The third objective is to describe what type of OTCs are reimbursed and under what conditions of...

Traffic Safety Administration, in the interest of information exchange. The opinions, findings, and conclusions expressed in this publication are those of the author(s) and not necessarily those of the Department of Transportation or the National Highway Traffic Safety Administration. The United States Government assumes no liability for its content or use thereof. If trade or manufacturers' na...

The rising influence of user-generated online reviews (Cone, 2011) has led to growing incentive for businesses to solicit and manufacture DECEPTIVE OPINION SPAM—fictitious reviews that have been deliberately written to sound authentic and deceive the reader. Recently, Ott et al. (2011) have introduced an opinion spam dataset containing gold standard deceptive positive hotel reviews. However, th...

☆ We thank Ross Rizley and gratefully acknowledge fu Institute under MSI Research Grant #4-1364. The first a port under grants SES 0452864 (“Marketing Character (“Advertising Themes”). We thank the Melbourne Busin Competition Authority for their hospitality. All authors t litical Economy at the University of Virginia. An early ver culated under the title of “Getting into Your Head(ache Analgesi...

We consider ensembles of sine-coupled phase oscillators consisting of subpopulations of identical units, with a general heterogeneous coupling between subpopulations. Using the Watanabe-Strogatz ansatz we reduce the dynamics of the ensemble to a relatively small number of dynamical variables plus microscopic constants of motion. This reduction is independent of the sizes of subpopulations and r...

The growing popularity of portable and mobile computing and communication devices along with the introduction of wireline broadband networks is fueling demand for wireless broadband networks. Since ATM has been accepted as the standard for broadband integrated service networks we consider the problem of providing \ATM-like services" to mobile devices. In this paper, we discuss the fundamental i...