background: temporal variation of stroke onset is suggested in some studies contained somewhat varieties. it is proposed that some predisposing changes occur in some ascertained times consequently resulted in stroke occurrence in some special times. objective: to determine the circadian and circaseptan variation of stroke onset. materials and methods: this cross sectional study was conducted fr...

background: leishmaniasis is a widespread problem, especially in the tropical and subtropical countries. since understanding epidemiologic and geographical distribution of the diseases is necessary for prevention and control of leishmaniasis. this study was conducted for epidemiological survey of cutaneous leishmaniasis in north khorasan province, using gis during the years 2006-2013.methods: i...

Public health encompasses a broad array of programs designed to prevent the occurrence of disease and injury within communities. But policy makers have little evidence to draw on when determining the value of investments in these program activities, which currently account for less than 5 percent of US health spending. We examine whether changes in spending by local public health agencies over ...

BACKGROUND Skeletal metastases represent an underappreciated site of metastasis in patients with pancreatic cancer. Previous reports have estimated the prevalence to range from 5 percent to 20 percent. With the use of gemcitabine and novel targeted agents such as erlotinib, there has been a modest increase in survival in patients with advanced pancreatic cancer. As such, it is anticipated that ...

The purpose of this note is to posit and discuss the concept of "competitive inhibition potential" (CIP), which is an in vivo index of the ability of a competitive inhibitor to elevate plasma concentrations of drug substrates, when the competitive inhibitor is administered at its usual and customary dose.