Networks, in which nodes represent compounds and edges pairwise similarity relationships, are used as coordinate-free representations of chemical space. So-called chemical space networks (CSNs) provide intuitive access to structural relationships within compound data sets and can be annotated with activity information. However, in such similarity-based networks, distances between compounds are ...

The synthesis of the title compound, bitamycin, by means of BU4NF is described. This new antiviral drug was found to be one of the most powerful and least toxic substances for antiviral therapy in man. The physical and chemical behavior as well as the antiviral activities and clinical properties of this compound were found to be significantly different from that reported by Schaeffer, et a...

Background & Aim: Kelussiaodoratissima Mozaff is a valuable plant of Apiaceae family that is used as medicinal and aromatic herb. According to the importance of drying treatment on quality and quantity of essential oil, the effect of different drying methods on essential oil yield and chemical composition of Kelussia odoratissima Mozaff was examined in this research. ...

dacarbazine (dtic) is a synthetic chemical antitumor agent which is used to treat malignant melanoma and hodgkin’s disease. dtic is a prodrug which is converted to an active form undergoing demethylation by liver enzymes. the active form prevents the progress of disease via alkylation of dna strand. in the structure of this drug, the imidazole ring, a triazen chain and carboxamide group exist. ...

ABSTRACT: Due to the importance of essential oils and their use in various industries, the essential oils of four types of citrus consisting of orange (C. sinesis), tangerine (C. reticulate), sweet lemon (C. limetta) and sour lemon (C. limon) were extracted and subjected to chemical analysis to identify and evaluate the chemical constituents of the oils. The average essential oils of orange, ta...

Background: Due to interesting tumor imaging properties of bis-thiosemicarbazones, [103Pd]-di-acetyl-bis (N4-methylthiosemicarbazone) ([103Pd] ATSM2) was prepared according to the analogy of radio copper homologues. Materials and Methods: Palladium-103 (T1/2=16.96 d) was produced via the 103Rh (p,n) 103Pd nuclear reaction with proton energy 18 MeV. The final activity was eluted in form of Pd ...