Elevated enzyme activities in plasma may sometimes be due to the presence of macroenzymes.1,2 Macroenzymes are high molecular mass complexes of plasma enzymes with immunoglobulins (IgG, IgA or IgM) or other plasma components with reduced plasma clearance and prolonged half life, resulting in elevated serum activities due to the “trapping” of the enzymes in serum.3 These results may thus be erro...

The causes of individuality of the plasma enzymes alanine aminotransferase (ALT; EC 2.6.1.2), aspartate aminotransferase (AST; EC 2.6.1.1) and gamma-glutamyl transferase (GGT; EC 2.3.2.2) were investigated in a study of 206 pairs of twins. Between-person variance was greater in men than women, while within-person variation was similar in both sexes. Plasma ALT and AST levels were affected by ge...

the effects of three  anesthetics, clove oil (co) ( 30 mgl-1), 2-phenoxy ethanol (2-pe) (0.3 mll-1), and ms-222 (100 mgl-1) were examined on blood enzymes including lactate dehydrogenase (ldh), creatine kinase (ck), alanine aminotransferase (alt), aspartate aminotransferase (ast), albumin, glucose, and cortisol levels in the caspian brown trout. blood parameters were evaluated in the control (n...

BACKGROUND Serum aminotransferase concentrations are reportedly strongly associated with insulin resistance, an established cardiovascular risk factor that is not routinely assessed in clinical practice. We therefore explored the possibility that serum aminotransferase concentrations are as closely related to large artery disease as insulin resistance in rheumatoid arthritis (RA). METHODS Car...

Markers of infectious-inflammatory process were studied by determining the levels pro-inflammatory cytokines - interleukin (IL) 1 and IL-6 proteins acute phase inflammation C-reactive protein (CRP) fibrinogen in serum children with community-acquired pneumonia. 
 It was found that course pneumonia is accompanied an increase concentrations IL-1 parallel disease severity. The synthesis stimu...

The present study was designed to reveal the hitherto unknown efficacy of two commonly used hepatoprotective drugs, L-ornithine-L-aspartate (lornit) and silymarin in the regulation of kidney toxicity and thyroid dysfunction in mice. Renal and hepatic lipid peroxidation (LPO) was induced by the administration of carbon tetrachloride (CCl4) for 2 weeks (2.0 gm/kg twice a week). In two separate gr...

background alanine aminotransferase (alt) level is the most common diagnostic test used for detection of liver damage; however in the past few years some studies have questioned the normal aminotransferase range in adults and have suggested its revision. objectives in this study, we assessed the upper limit of alt and aspartate transaminase (ast) in a healthy population of iranian children. pat...

Although elevation of the levels of serum alanine aminotransferase (ALT) following liver injury is well known, confusion exists concerning skeletal muscle injury as the cause of this rise. We reviewed the records of 16 patients who had muscle necrosis without evidence of liver disease. The patients were divided into three groups: extreme exercise, polymyositis, and seizures. All patients exhibi...

Aflatoxins are a group of secondary fungal metabolites that occur widely in natural contaminants of many feeds under high humidity and temperature, and are potentially dangerous to fish. Therefore, this study was designed to investigate the effects of aflatoxins on some plasma biochemical indices, as clinical biomarkers, in common carp, Cyprinus carpio. Fish were fed diets contaminated with 0 (...