Humans, chimpanzees and all Old World monkeys tested to date are able to taste the sweet compounds acesulfame-K, aspartame, D-tryptophan, sucrose, xylitol, monellin and thaumatin. In humans and chimpanzees, but not in rhesus macaques, gymnemic acid suppresses or abolishes the chorda tympani proper nerve response and the sweet taste of these compounds. This study examines the relationship betwee...

Systematic surface energy modifications to glass substrates can induce nucleation and improve crystallization outcomes for small molecule active pharmaceutical ingredients (APIs) and proteins. A comparatively broad probe for function is presented in which various APIs, proteins, organic solvents, aqueous media, surface energy motifs, crystallization methods, form factors, and flat and convex su...

Riboflavin-binding protein (RBP) is well known as a riboflavin carrier protein in chicken egg and serum. A novel function of RBP was found as a sweet-suppressing protein. RBP, purified from hen egg white, suppressed the sweetness of protein sweeteners such as thaumatin, monellin, and lysozyme, whereas it did not suppress the sweetness of low molecular weight sweeteners such as sucrose, glycine,...