Epithelial barrier integrity is of outermost importance to protect the human body from external harm. One key cytokines involved in tissue regeneration interleukin (IL)-22. During inflammation, IL-22 producing cells are recruited into organs restore inflammation mediated damage. The aryl hydrocarbon receptor (AhR) has been shown regulate expression T cells. Previous results our group indicated ...

Our knowledge of atopic dermatitis/AD is largely derived from whole skin biopsies, which may cause scarring and infection. Tape strips are a minimally invasive technique to collect samples. A study directly differentiating the two approaches unavailable. We thus compared transcriptomic profile lesional AD as captured by tape biopsies taken 20 moderate-to-severe patients healthy controls. perfor...

Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by persistent, severe itch and firm nodules on the extremities trunk. The immunophenotype of PN thought to involve multiple immune axes, with varying cutaneous blood involvement T-helper (Th) responses, including Th1, Th2, Th17, Th22 cytokines. Here, we investigated role Th2-related cytokines IL-13, IL-4, IL-5 along pan...