نتایج جستجو برای: th2 response

تعداد نتایج: 984435  

Journal: :Journal of immunology 1998
M Desmedt P Rottiers H Dooms W Fiers J Grooten

Differentiation of naive CD4+ T cells (Th0) into Th1 or Th2 cells determines whether antigen will raise a cellular or a humoral immune response. The maturation pathway chosen by the Th0 cell is often decisive for the outcome of disease and depends among others on the (co-)stimulatory attributes of the APC and the nature and abundance of cytokines provided by the APC and the microenvironment. In...

2011
Patrizia Pellegrini Ida Contasta Tiziana Del Beato Fabiana Ciccone Anna Maria Berghella

Studies focusing on gender have shown that differences exist in how the immune system responds to disease and therapy. Understanding how gender influences immunological mechanisms in health and disease and identifying gender-specific biomarkers could lead to specifically tailored treatment and ultimately improve therapeutic success rates. T helper1 (Th1) and Th2 cytokines (Th1/Th2) have pivotal...

Journal: :Infection and immunity 2002
Sharon R Chirgwin Philip H Elzer Sharon U Coleman Jena M Nowling Sue D Hagius Matthew D Edmonds Thomas R Klei

Filarial infections have been associated with the development of a strongly polarized Th2 host immune response and a severe impairment of mitogen-driven proliferation and type 1 cytokine production in mice and humans. The role of this polarization in the development of the broad spectra of clinical manifestations of lymphatic filariasis is still unknown. Recently, data gathered from humans as w...

Journal: :The Journal of Experimental Medicine 1996
E Murphy K Shibuya N Hosken P Openshaw V Maino K Davis K Murphy A O'Garra

Commitment of T helper 1 (Th1) or Th2 populations developing during an immune response to a pathogen, or an inappropriate immune response to an allergen or autoantigen, may determine the difference between health and chronic disease. We show that strongly polarized Th1 and Th2 populations assessed by immunoassay are heterogeneous using flow cytometry to detect single cells producing interferon ...

Journal: :The Journal of Experimental Medicine 2006
Qun Wang Rachel M. McLoughlin Brian A. Cobb Marie Charrel-Dennis Kathleen J. Zaleski Douglas Golenbock Arthur O. Tzianabos Dennis L. Kasper

Commensalism is critical to a healthy Th1/Th2 cell balance. Polysaccharide A (PSA), which is produced by the intestinal commensal Bacteroides fragilis, activates CD4+ T cells, resulting in a Th1 response correcting the Th2 cell skew of germ-free mice. We identify Toll-like receptors as crucial to the convergence of innate and adaptive responses stimulated by PSA. Optimization of the Th1 cytokin...

2015
Eva Verjans Kim Ohl Lucy K. Reiss Femke van Wijk Antonaneta A. Toncheva Anastasia Wiener Yin Yu Annette D. Rieg Vincent D. Gaertner Johannes Roth Edward Knol Michael Kabesch Norbert Wagner Stefan Uhlig Christian Martin Klaus Tenbrock

A characteristic feature of allergic diseases is the appearance of a subset of CD4+ cells known as TH2 cells, which is controlled by transcriptional and epigenetic mechanisms. We aimed to analyze the role of CREM, a known transcriptional activator of T cells, with regard to TH2 responses and allergic diseases in men and mice. Here we demonstrate that T cells of asthmatic children and PBMCs of a...

2014
Julie A. Cakebread Hans Michael Haitchi Yunhe Xu Stephen T. Holgate Graham Roberts Donna E. Davies

BACKGROUND In response to viral infection, bronchial epithelial cells increase inflammatory cytokine release to activate the immune response and curtail viral replication. In atopic asthma, enhanced expression of Th2 cytokines is observed and we postulated that Th2 cytokines may augment the effects of rhinovirus-induced inflammation. METHODS Primary bronchial epithelial cell cultures from ped...

Journal: :Journal of immunology 2008
Stephen J Jenkins Georgia Perona-Wright Andrew S MacDonald

The CD40-CD154 interaction is critical for Th2 response generation during helminth infection and following immunization with helminth-conditioned dendritic cells, yet the key cellular sources of these molecules have still to be defined in vivo. In this study, we demonstrate that the requirement for CD40 expression during murine Th2 response induction is restricted exclusively to the Ag-bearing ...

Journal: :The Journal of Experimental Medicine 1997
Susanne J. Szabo Anand S. Dighe Ueli Gubler Kenneth M. Murphy

The developmental commitment to a T helper 1 (Th1)- or Th2-type response can significantly influence host immunity to pathogens. Extinction of the IL-12 signaling pathway during early Th2 development provides a mechanism that allows stable phenotype commitment. In this report we demonstrate that extinction of IL-12 signaling in early Th2 cells results from a selective loss of IL-12 receptor (IL...

Journal: :reports of biochemistry and molecular biology 0
maryam shahi tel: +98 02633 311122511; fax: +98 511- 5091172 masoud mohajery parasitology & medical mycology department, mashhad university of medical sciences mashhad, iran seyyed ali akbar shamsian parasitology & medical mycology department, mashhad university of medical sciences mashhad, iran hossein nahrevanian parasitology departmen, pasteur institute of iran, tehran, iran. seyyed mohammad javad yazdanpanah parasitology & medical mycology department, mashhad university of medical sciences mashhad, iran

background: cutaneous leishmaniasis is an endemic disease in many regions of iran, including the city of mashhad. in recent years, some cases have not responded to glucantime, the usual treatment for this disease. the cellular immune response caused by t-helper type 1 (th1) cells has an important role in protection against leishmaniasis, and activation of the t-helper type 2 (th2) response caus...

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