نتایج جستجو برای: tgfβ
تعداد نتایج: 3626 فیلتر نتایج به سال:
Transforming growth factor-β (TGFβ) is activated as a result of liver injury, such as cholestasis. However, its influence on endogenous metabolism is not known. This study demonstrated that TGFβ regulates hepatic phospholipid and bile acid homeostasis through MAD homolog 3 (SMAD3) activation as revealed by lithocholic acid-induced experimental intrahepatic cholestasis. Lithocholic acid (LCA) in...
High levels of transforming growth factor-β (TGFβ) correlate with poor prognosis for patients with prostate cancer and other cancers. TGFβ is a multifunctional cytokine and crucial regulator of cell fate, such as epithelial to mesenchymal transition (EMT), which is implicated in cancer invasion and progression. TGFβ conveys its signals upon binding to type I and type II serine/threonine kinase ...
Growth factor signaling results in dramatic phenotypic changes in cells, which require commensurate alterations in cellular metabolism. Mutations in SLC2A10/GLUT10, a member of the facilitative glucose transporter family, are associated with altered transforming growth factor-β (TGFβ) signaling in patients with arterial tortuosity syndrome (ATS). The objective of this work was to test whether S...
BACKGROUND Hyaline cartilage tissue of joints is susceptible to injuries due to avascularity. Mesenchymal stem cells (MSCs) are used for cartilage tissue engineering. Among MSCs, adipose stem cells (ASCs) are attractive because of accessibility, their large number, and rapid growth. Common in vitro protocols successfully induce chondrogenic differentiation by expression of multiple cartilage-sp...
Signal transduction controls cellular and tissue responses to radiation. Transforming growth factor beta (TGFβ) is animportant regulator of cell growth and differentiation and tissue homeostasis, and is often dis-regulated in tumorformation. Mathematical models of signal transduction pathways can be used to elucidate how signal transductionvaries with radiation quality, and dose and...
We present a novel mathematical model for collagen deposition and alignment during dermal wound healing, focusing on the regulatory effects of TGFβ. Our work extends a previously developed model which considers the interactions between fibroblasts and extracellular matrix, composed of collagen and a fibrin based blood clot, by allowing fibroblasts to orient the collagen matrix, and produce and ...
در سالهای اخیر جهشهایی با اثرات عمده روی نرخ تخمکریزی در دو جایگاه ژنی مربوط به لیگاندهای tgfβ و نیز گیرندههای مربوط به tgfβ شناسایی شده است. این مطالعه برای شناسایی چندشکلیهای مربوط به لیگاندهای bmp15 (واریانت b4) و gdf9 (واریانتg1) در گوسفند دالاق انجام شد. 100 نمونه خون از دو گله در سطح شهرستان گنبد کاووس جمعآوری شد و استخراج dna به روش بهینه یافته نمکی انجام گرفت. با استفاده از دو ...
TGFβ-induced expression of the NADPH oxidase Nox4 is essential for fibroblast-myofibroblast transition. Rho has been implicated in Nox4 regulation, but the underlying mechanisms are largely unknown. Myocardin-related transcription factor (MRTF), a Rho/actin polymerization-controlled coactivator of serum response factor, drives myofibroblast transition from various precursors. We have shown that...
Astrocytes limit inflammation after CNS injury, at least partially by physically containing it within an astrocytic scar at the injury border. We report here that astrocytic transforming growth factor-beta (TGFβ) signaling is a second, distinct mechanism that astrocytes utilize to limit neuroinflammation. TGFβs are anti-inflammatory and neuroprotective cytokines that are upregulated subacutely ...
Transforming growth factor-β (TGFβ) is an important driver of tumor growth via intrinsic and extrinsic mechanisms, and is therefore an attractive target for developing cancer therapeutics. Using preclinical models, we characterized the anti-tumor activity of a small molecule inhibitor of TGFβ receptor I (TGFβRI), galunisertib (LY2157299 monohydrate). Galunisertib demonstrated potent and selecti...
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