Abstract The sulfoximine-based tetrazoles have been synthesized via azido-Ugi four-component reactions of sulfoximines, isocyanides, aldehydes, and TMS-azide in MeOH at 70 °C the presence InCl3. Replacement sulfoximines with sulfonimidamides (SIA) has delivered corresponding SIA-based tetrazole. Interestingly, SIA also acts as a surrogate amine to furnish aminotetrazole by-product.

Linear and cyclic hymenistatin I (HS I) analogues with dipeptide segments Ile2-Pro3 Pro3-Pro4 and Val6-Pro7 replaced by their tetrazole analogues Ile2-psi[CN4]-Ala3', Pro3-psi[CN4]-Ala4 and Val6-psi[CN4]-Ala7 were synthesized by the solid phase peptide synthesis method and cyclized with the TBTU and/or HATU reagent. The peptides were examined for their immunosuppressive activity in the lymphocy...

The mol-ecule of the title compound, C(4)H(8)N(6), assumes an approximately planar structure, the methyl C atoms and the C atom to which they are bonded being out of the mean tetrazole ring plane by 0.108 and 0.139, and 0.144 Å, respectively. π-π stacking between parallel tetra-zole rings [centroid-centroid distance = 3.4663 (11) Å] is observed in the crystal structure. Inter-molecular N-H⋯N hy...

A colorimetric method using a tetrazolium compound, 3,4,5-dimethylthiozalil-(1 or 2),2,5-diphenyltetrazolium bromide (TTBr), was developed for studying the growth activity of yeast-phase Histoplasma capsulatum. Materials extracted in phosphate buffer, pH 7.0, from cells at different stages of growth reduced TTBr. Colorimetric changes were correlated with enzymatic activity. Under standardized c...

Eight different derivatives of substituted 5-phenyl-1-(5-substituted phenyl) -4,5-dihydro1H-pyrazol-3-yl)-1H-tetrazole (4a-h) were synthesized by reacting the chalcones with hydrazine hydrate in presence of glacial acetic. The chemical structures were confirmed by means of FT-IR, H-NMR, mass spectra and elemental analysis. The compounds were screened for analgesic activity by acetic acid induce...

DESCRIPTION TEVETEN HCT 600/12.5 mg and TEVETEN HCT 600/25 mg (eprosartan mesylate­ hydrochlorothiazide) combine an angiotensin II receptor (AT1 subtype) antagonist and a diuretic, hydrochlorothiazide. TEVETEN (eprosartan mesylate) is a non-biphenyl non-tetrazole angiotensin II receptor (AT1) antagonist. A selective non-peptide molecule, TEVETEN is chemically described as the monomethanesulfona...

A series of methyl 6-Chloro-2-Substitued-1-[2-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]1H-benzoimidazol-5-ylamine were successfully synthesized. Benzimidazoles were prepared by condensation of 4-chloro-o-phenylenediamine with substituted aryl, aldehyde condensation with biphenyl tetrazole group and reduction stannous chloride dihydrate. An insertion-cyclization strategy was involved during synthe...

A three-dimensional mixed-valence iron complex with NiAs-type topology, [(Fe(III)(3)O)Fe(II)(TA)(6)(H(2)O)(3)].(ClO(4))(2)(NO(3))(EtOH)(H(2)O)(2) (1, HTA = tetrazole-1H-acetic acid), shows spin-crossover behavior that was characterized via variable-temperature crystal structures, Mössbauer spectra and magnetic susceptibilities, the pressure effects on the transition behavior were also studied.

Four coordinate tetrahedral (Pd0 and Pt0) and square planar (Rh+ and Ir+) complexes of triphenyl phosphine and 1-benzyl tetrazoline-5-thione have been prepared and characterised on the basis of elemental analysis and spectroscopic data (IR, UV-vis, 1HNMR). Bonding of tetrazole ligand occurs through thione tautometric form. Determination of oxidation state of central metal atom in the complexes ...

New tetrazole analogues with bio-active cores have been synthesized by a novel synthetic methodology. The synthesized compounds were characterized using FT-IR, MS, elemental analysis, H, C and HSQC NMR spectroscopic techniques. The synthesized compounds were screened for their antibacterial activities against Staphylococcus aureus, Escherichia coli, Vibreo cholerae, Pseudomonas aeruginosa and K...