The combination of palladium catalysis and thermal cycloaddition is shown to transform tricyclic aziridines into complex, stereodefined tetracyclic products in a single step. This highly unusual cascade process involves diverted Tsuji–Trost sequence leading surprisingly facile intramolecular Diels–Alder reaction. starting materials are accessible on multigram scales from the photochemical rearr...

distance-balanced graphs are introduced as graphs in which every edge uv has the followingproperty: the number of vertices closer to u than to v is equal to the number of vertices closerto v than to u. basic properties of these graphs are obtained. in this paper, we study theconditions under which some graph operations produce a distance-balanced graph.

Fluorescence properties of two new potential antitumoral tetracyclic thieno[3,2-b]pyridine derivatives were studied in solution and in liposomes of DPPC (dipalmitoyl phosphatidylcholine), egg lecithin (phosphatidylcholine from egg yolk; Egg-PC) and DODAB (dioctadecyldimethylammonium bromide). Compound 1, pyrido[2',3':3,2]thieno[4,5-d]pyrido[1,2-a]pyrimidin-6-one, exhibits reasonably high fluore...

The first total synthesis of the dimeric alkaloid pigment scytonemin is described. The key transformations in its synthesis from 3-indole acetic acid are a Heck carbocyclization and a Suzuki-Miyaura cross-coupling, orchestrated in a stereospecific tandem fashion, followed by a biosynthetically inspired oxidative dimerization. The tandem sequence generates a tetracyclic (E)-3-(arylidene)-3,4-dih...

a special class of cubic graphs are the cycle permutation graphs. a cycle permutation graph pn(α) is defined by taking two vertex-disjoint cycles on n vertices and adding a matching between the vertices of the two cycles.in this paper we determine a good upper bound for tenacity of cycle permutation graphs.

the total version of geometric–arithmetic index of graphs is introduced based on the endvertexdegrees of edges of their total graphs. in this paper, beside of computing the total gaindex for some graphs, its some properties especially lower and upper bounds are obtained.

An enantioselective total synthesis of the Strychnos alkaloid (+)-minfiensine has been accomplished. Prominent features of this synthesis include (i) a new enantioselective organocatalytic Diels-Alder/amine cyclization sequence to build the central tetracyclic pyrroloindoline framework in four steps from commercial materials and (ii) a 6-exo-dig radical cyclization to forge the final piperidiny...

A new route to podolactones functionalized in the A ring has been achieved. Two key steps were employed in this synthesis, the construction of the bicyclic skeleton via a Mn(III)-mediated radical cyclization and the transformation of this bicyclic intermediate into the tetracyclic podolactone skeleton through a Pd (II)-mediated bislactonization of the corresponding conjugate diene. The reported...