Introduction: Vaccination has been the most effective human intervention in alleviating human sufferings and death. Vaccine production in Iran has a long history however, in the face of a changing global landscape, it requires a new roadmap for research, development and production in the coming decades. Methods: This document was drafted based on Article A of the “Comprehensive National S...

Influenza viruses continue to be a major health threat in human and bird populations. The improvements in formulation and production level of the current influenza vaccines are not sufficient to afford complete protection. The continuous antigenic drifts and emergence of endemic and zoonotic strains make influenza vaccine planning difficult. Concern about the emergence of new influenza pandemic...

for evaluation the stability and potency of anthrax vaccine prepared in razi vaccine and serum research institute in iran, samples of different batches of vaccine were kept at 4-8 °c (refrigerator), 20-25 °c (room temperature) and 37 °c (incubator).the viable spores/ml of vaccines were determined using plate–counting method before and after holding at different temperatures monthly. vaccine pot...

objective: today, aids is considered as a global problem and many efforts to generate an effective vaccine against this disease have been made, but remain inconclusive. dna vaccines are a member of the new generation of vaccines that can efficiently stimulate the immune system. however, recent findings indicate low immunogenicity for these vaccines and it is believed that these types of vaccine...

Vaccine misinformation online may contribute to the increase of anti-vaccine sentiment and vaccine-hesitant behaviors. Social network data was used identify Twitter vaccine influencers, their twitter communities, geolocations determine pro-vaccine communities. We explored 139,433 tweets identified 420 influencers—opinion leaders assessed 13,487 7,731 connections. Semantic analysis employed conv...

Abstract Background and Aims: For more than half a century, the production of fowl pox vaccine at Razi Vaccine and Serum Research Institute, has been carried out by injection method in the chick chorioallantoic membrane (CAM) and the vaccine has a favorable and effective in poultry flocks and has provided a complete satisfaction to the poultry flocks owner. Fowl pox vaccine is also manufactured...

Bovine brucellosis is a zoonotic disease distributed worldwide and characterized by abortion and reducedfertility in cows. Since brucellosis eradication programme in Iran uses vaccination, test, slaughter andquarantine as control measures, it is essential to distinguish vaccine strains from strains that cause infectionsamong vaccinated cattle herds. We developed and evaluated a multiplex polyme...

Recombinant proteins are tending to be the most favorable vaccine-candidates against botulism. Recombinant Carboxy-terminal of botulinum neurotoxin serotype E (rBoNT/E-HCC) has been introduced as an efficient vaccine against botulism type E. In this report, we made an effort to investigate the effect of different pH on protein structure to assess if rBoNT/E-HCC could be used as a vaccine for or...

A field trial was canied outon60 volunteers selected in Yazd province, central Iran, with a vaccine containing killed promastigotes of L. major prepared by the Razi Institute, Hessarak. During these phase I studies which lasted for more than two years, we examined acceptable doses of the vaccine alone or mixed with BCG. The results so far indicate that 50 to 1000 µg of the vaccine alone can...