Onchocerca volvulus infection has been associated with impaired cellular responses to parasite antigens, an impairment that may also extend to nonparasite antigens. To investigate the mechanism of this impaired immune response, the effect of concurrent O. volvulus infection on the immune response to tetanus toxoid (TT) following tetanus vaccination was studied. The proliferative, cytokine, and ...

PURPOSE Recombinant subunit vaccines provide safe and targeted protection against microbial infections. However, the protective efficacy of recombinant subunit vaccines tends to be less potent than the whole cell vaccines, especially when they are administered through mucosal routes. We have reported that a bacterial flagellin has strong mucosal adjuvant activity to induce protective immune res...

introduction cephalic tetanus is a rare form of tetanus, defined as trismus and cranial nerve palsy. it has a mortality rate of 15 - 30%. case presentation the purpose of this case report was to present a case of cephalic tetanus with trismus, a rare form of tetanus, in an intravenous drug abuser. timely diagnosis and management prevented progression into the generalized form and made the patie...

On binding of antibody to antigen an immune complex is formed that has a net surface charge different from that of either of the two components. This, together with clonal restriction of the antibody response, gives rise to distinctive patterns that are readily apparent in stained agarose gels after routine zone electrophoresis. Most circulating immune complexes appear as a rectangular pattern,...

Human immune serum globulin (HISG) therapy is the mainstay of treatment for patients with antibody immunodeficiency. Treatment with ‘y-globulin allows many of these patients to remain symptomfree for prolonged periods. Three types of human immunoglobulin are available for therapeutic use: (1) regular HISG for intramuscular (IM) use, derived from a panel of normal donors, therefore containing a ...

Fragment B of tetanus toxin (Helting, T. B., and Zwisler, 0. (197’7) J. Biol. Chem. 252, 187-193), obtained after digestion with papain, gel chromatography, immunoabsorption, and repeated gel chromatography, was atoxic in experimenta’l animals at concentration levels sufficient to induce protective antibody synthesis. However, mice injected with 200 pg of highly purified Fragment B appear norma...

This study evaluated the effectiveness and usefulness of vaccination against diphtheria and tetanus in different age groups in Gaza, Palestine. Blood samples were collected from 180 children aged <12 years, 90 males and 90 females. Using ELISA methods, the efficacy of vaccination was estimated at 87.8% for diphtheria and 98.3% for tetanus. Mean serum titres varied significantly by age group: fo...

Human antibody to diphtheria toxin was analyzed with an ammonium sulfate radioimmunoassay. In 15 immune sera with titers of between 0.03 and 25 units/ml, the avidity was similar to that of U.S. standard antitoxin. The proportion of the post-immunization anti-diphtheria antibody specific for fragment A was variable, but in the 10 sera tested constituted a substantial fraction of the antibody. Ap...

The aim of this study was to investigate an antibody response to tetanus toxoid in iron-deficient piglets. Ten piglets were not given any iron preparation until the age of 21 days. Ten piglets were given 200 mg Fe3+ dextran intramuscularly at the age of 3 days. All piglets were immunized with tetanus toxoid 14 days after birth. Reimmunization was performed 21 days after the first immunization. ...

To define epitopes of tetanus toxin, we compared four different in vitro systems in terms of their ability to produce tetanus toxin-specific subfragments from cloned DNA. A transcription-translation system developed from a nontoxigenic strain of Clostridium tetani was found to yield predominantly full-sized peptides. Such peptides were used to map six different epitopes for eight monoclonal ant...