results: this study showed significantly lowered concentrations of testosterone (3.11 nm/l ± 0.34) and hdl (0.39 mmol/l ± 0.02), in addition to the expected increased concentrations of fasting plasma glucose (9.61 mmol/l ± 0.37) in the subjects compared to controls (p < 0.05). an inverse significant correlation was observed between the serum testosterone concentration and metabolic syndrome (bm...

Under the clinical impression that patients with chronic obstructive pulmonary disease (COPD) may demonstrate signs compatible with hypogonadism, we investigated whether oral glucocorticoid therapy is associated with testosterone deficiency. Thirty six men with COPD of whom 16 were receiving oral glucocorticoid medication (mean+/-SEM dose 9.4+/-1.1 mg prednisolone) were investigated in a cross-...

Neonu/a/ antiandrogens and organi::ution of' behavioral se.r c/Uferences i11 the ml (Rattus norvegicus).The role or androgens in the masculinization and later activation of socio­ sexual hehavior. was studied in the following experimental groups or Wistar rats: control males (MAL): peripuberLally castrated males (GON): peripubertally castrated males supplied with testosterone propionate in ,1du...

Testicular prostheses have been used to deal with anorchia for nearly 80 years. Here, we evaluated a novel testicular prosthesis that can controllably release hormones to maintain physiological levels of testosterone in vivo for a long time. Silastic testicular prostheses with controlled release of testosterone (STPT) with different dosages of testosterone undecanoate (TU) were prepared and imp...

A series of atomistic molecular dynamics simulations were performed for investigating the interactions between three different testosterone-based compounds (testosterone (T), testosterone propionate (TP) and testosterone enanthate (TE)) and sodium dodecyl sulphate (SDS) and ammonium dodecyl sulphate (ADS) monolayers, which vary only in the sodium or ammonium counterions used to neutralise the s...

We studied the effects of castration and testosterone (T) replacement on intracavernous pressure (ICP) elicited with electrical stimulation of the medial preoptic area (MPOA) and cavernous nerve (CN) in male rats. We measured the ICP during electrical stimulation of the MPOA and CN in castrated male rats with and without testosterone replacement. The experimental group consisted of 20-week-old ...

A rela t ionship be tween estrogenic activity and the product ion of tumors of the m a m m a r y g land has been clearly demons t r a t ed in various strains of mice. In v iew of the inh ib i tory action of testosterone on estrus, lactation, and the vaginal response to estrone in mice (4, 5), t he possibility of affecting spontaneous t u m o r format ion by inhib i t ion of estrogenic activity ...

Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated T-cells (NFAT) is associated with the promotion of cardiac hypertrophy, glycogen synthase kinase-3β (GSK-3β) is considered to function as a negative regulator, mainly by modulating NFAT activity. However, the role played b...

OBJECTIVES To determine the relationship between serum levels of B cell activating factor belonging to the TNF family (BAFF) and disease activity (DAS28) in psoriatic arthritis (PsA) patients. METHODS Twenty-two male and 31 female psoriasis patients fulfilling the CASPAR criteria for PsA were recruited for the study. Disease activity was recorded using the disease activity score for 28 joints...

Christina Wang and colleagues conducted a randomized trial in two centers (California, USA and China) with two treatment groups (non-Chinese and Chinese men, respectively, 40 subjects each group). The primary aim of the study was to compare the efficacy of the combination of the progestin levonorgestrel (LNG) with testosterone (T) implants to that by T implants alone on spermatogenesis suppress...