نتایج جستجو برای: testis cells
تعداد نتایج: 1398353 فیلتر نتایج به سال:
A domestic ferret was submitted for sterilisation because of right testis enlargement. Oestradiol and cortisol concentrations were within normal physiological ranges, but testosterone was below and progesterone above normal. Microscopically, the right testis, with the exception of a small part of the epididymis, was replaced with neoplastic tissue. The tumour was composed of streams and bundles...
Introduction. Macrophages are cells of the innate immune system that play many roles in body. known to be found endocrine glands, and there is now much evidence these interact closely with cells. Immune-endocrine interactions important for development glands their functioning during physiological states, also become key players pathophysiological states. Through gene expression profiling, diver...
background: vitamin e is an effective antioxidant, protecting cells against oxidative stress. objective: in this investigation the protective effect of vitamin e on the testis during development and spermatogenesis in rats exposed to sodium arsenite was evaluated. materials and methods: pregnant wistar rats were divided into 4 groups (n=8) control, sodium arsenite (8 mg/kg/day), sodium arsenite...
introduction: cryptorchidism has been proved to cause apoptosis in germ cells in respond to changes in the stimulation levels of specific physiological events. the purpose of this study was to determine whether treatment of bilateral cryptorchidism was associated with alterations in testicular gene expression. methods: to induce bilateral cryptorchid model, immature mice were anesthetized and a...
Leydig cells are the major source of androgen in the male mammal. We describe here for the first time the development of the Leydig cell in a macropodid marsupial, the tammar wallaby, Macropus eugenii. Leydig cells are first recognized morphologically 2 days after birth with the appearance of lipid droplets in the cytoplasm of certain interstitial cells. Lipid content closely matches the steroi...
Background: Ciprofloxacin was shown to have cytotoxic effects on testicular germ cells. Its mechanism of cytotoxic action is not fully understood. To investigate the possibility of the involvement of an oxidative stress induction in this mechanism, total antioxidant power (TAOP) in the testis was evaluated. Materials and Methods: A number of twenty four mature male NMRI mice were used.The anima...
Background: In vitro spermatogenesis has a long research history beginning in the early 20th century. This organ culture method was therefore abandoned, and alternative cell culture methods were chosen by many researchers. Here, whether Tnp1, Tekt1, and Plzf, which play a crucial role in spermatogenesis, can be expressed during testis organ culture was assessed. Methods: Testes of 10 mouse pups...
Background: About 15% of couples have fertility problems and male factor in fertility accounts for half of the cases. In vitro generation of germ cells introduces a novel approach to male infertility and provides an effective system in gene tracking studies, however many aspects of this process have remained unclear. We aimed to promote mouse embryonic stem cells (mESCs) differentiation into ge...
BACKGROUND The high mobility group box chromosomal protein 1 (HMGB1) was originally shown to be a nuclear DNA-binding protein that activates transcription and promotes differentiation. More recently, there have been reports that HMGB1 may also function as a pro-inflammatory and antibacterial factor. The aim of this study was to investigate the testicular expression and antibacterial functions o...
BACKGROUND Given the significant drawbacks of using human embryonic stem (hES) cells for regenerative medicine, the search for alternative sources of multipotent cells is ongoing. Studies in mice have shown that multipotent ES-like cells can be derived from neonatal and adult testis. Here we report the derivation of ES-like cells from adult human testis. METHODS Testis material was donated fo...
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