Arsenic (As), a well-known water pollutant, has been associated with various human health problems, however, studies pertaining to its reproductive toxicity on fish are very limited. In this study, we investigated the direct influence of As on fish spermatogenesis using Japanese eel (Anguilla japonica) in vitro testicular organ culture system. Eel testicular fragments were cultured in vitro wit...

Effect of arsenic was studied on the testicular tissue of Swiss albino mice. Sodium-meta-arsenite (NaAsO2) was administered to adult mice (25 +/- 30 g) at a dose level of 30 mg/L and 40 mg/L through drinking water for 30, 45 and 60 days. After the treatment, the testicular organ was removed, weighed and processed for histopathological observation. No change in the body weight was recorded in tr...

Curcumin as an antioxidant plays important role in reducing lead toxicity. This research aimed to demonstrate the potential of curcumin maintaining epithelial thickness and diameter seminiferous tubules mice treated with acetate. Thirty BALB/c (Mus musculus) were divided into 5 groups. Group N was negative control group no treatment. P positive group, which given 0.075 g/kgBW acetate once a day...

Tetramethylthiuram disulphide (Thiram), a dithiocarbamate fungicide was administered to male rats through gavage at dose 5, 10 and 25 mg/kg/day for 30, 60 and 90 days. A significant increase in relative testes weight (GSI) was observed at dose (25 mg/kg/d) after 90 days exposure, associated with mild pathomorphological changes. This included degeneration of seminiferous tubules with sloughing o...

Introduction The advances in the treatment of testicular cancer are among the great achievements in medicine. Cancer researchers from around the globe have asked and answered nearly every fundamental question about the treatment of patients with testicular cancer. The results are astonishing: cure in 95% of all patients; refined surgical techniques that preserve sexual function; minimization of...

The stimulation of oxidative stress and lipid peroxidation of liver tissues by AFB1 has been extensively investigated. However, the effect of AFB1 on antioxidant enzyme activities and gene expression in testis has not been completely elucidated. The current study investigated the histopathological picture and activities in addition to gene expression of antioxidant enzymes in testis of rats int...

AIM To evaluate the protective/ameliorative effects of vitamin E (vit E) on ethane dimethane sulfonate (EDS)-induced testicular toxicity in rats. METHODS The rats were assigned to eight groups, seven rats in each, and were injected intraperitoneally with vehicle, a single dose of ethane dimethane sulfonate (EDS) (75 mg/kg bodyweight), vit E (100 mg/kg bodyweight) or EDS + vit E for 3? days. T...