Correspondence: Donika Dimova Institute of Expeimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl., 25, BG-1113, Sofia, Bulgaria. Tel.: +359 2 972336 e-mail: [email protected] ABSTRACT Spermatogenesis is a complex process by which spermatogonial stem cells selfrenew and differentiate into spermatozoa under the elaborate coo...

The aim of this study was to determine the mechanisms driving the protective effects of squid ink polysaccharide (SIP) against cyclophosphamide (CP)-induced testicular damage, focusing on germ cells. In the testes of mice exposed to CP and/or SIP, the present study examined the levels of reactive oxygen species (ROS) and malondialdehyde, activity of superoxide dismutase levels, protein expressi...

PURPOSE To determine enzymatic antioxidant and lipid peroxidation levels in seminal plasma of patients orchiectomized for testicular tumors. MATERIALS AND METHODS The study included 52 patients: 26 control men and 26 orchiectomized patients for testicular tumor, of which 12 men had seminoma tumor and 14 men non-seminoma tumor. After semen analysis performed according to the WHO guidelines, an...

The potential of spermatozoa to become motile during post-testicular maturation, and the relationship between the cytoplasmic droplet and fertilizing capacity are reviewed. Post-testicular maturation of spermatozoa involves the autonomous induction of motility, which can occur in vivo in testes with occluded excurrent ducts and in vitro in testicular explants, and artefactual changes in morphol...

BACKGROUND Cisplatin, an effective antineoplastic agent, damages normal cells in a manner related to chemotherapy. Acetyl L-carnitine protects cells against mitochondrial and nuclear damage induced by chemotherapy. AIMS Animal experiment. STUDY DESIGN The aim of this study was to examine the protective effects of acetyl L-carnitine on cisplatin-induced gonadotoxicity in testicular structure...

The protective effects of Septilin (herbal extract) against radiation-induced damage in testis of male rats have been studied Animals were divided into four main groups: 1Control group, 2Septilin group (100mg/kg body weight/day). 3Irradiated group (4Gy gamma-radiation), 4Protected group in which animals (Male rats) were given Septilin orally (100mg/kg body weight/day) for two weeks before radia...

PURPOSE To investigate the protective effects of lipoxin A4 (LXA4) in rat testis injury following testicular torsion/detorsion. METHODS A rat testicular torsion model has been established as described. Rats were randomly divided into 6 groups: sham group, torsion group, torsion/detorsion (T/D) group, and T/D plus LXA4-pretreated groups (3 subgroups). Rats in LXA4-pretreated groups received LX...

Histopathology of testicular tissue is considered to be the most sensitive tool to detect adverse effects on male reproduction. When assessing tissue damage, seminiferous epithelium needs to be classified into different stages to detect certain cell damages; but stage identification is a demanding task. The authors present a method to identify the 12 stages in mink testicular tissue. The stagin...

This study describes the induction of chemosterilization in three groups each of six adult male Black Bengal goats at 30 days after a single bilateral intratesticular injection of a calcium chloride (CaCl(2), 2H(2)O) solution at the doses of 10, 20 or 40 mg/kg body weight/testis, always in a 2 ml volume of normal saline. Another one group of animals received only 2 ml of normal saline per testi...

Objective: Monosodium glutamate (MSG) is a widely used food additive with controversial side effects. Though neonatal administration of MSG has been shown to affect fertility via arcuate nucleus ablation, the body of work involving the effects of adult MSG administration on male rat fertility has yet to be collectively assessed. Design: Systematic review. Methods: A PubMed search using terms “m...