Sertoli cells are involved in the control of spermatogenesis. In adult animals, the Sertoli cell stocks, fixed before puberty, are highly correlated with those of the germ cells. Some factors influencing Sertoli cell stock formation have been analyzed: 1) Early hemicastration of impuberal animals showed that the proliferative activities of the Sertoli and the germ cells before puberty, rather t...

Mixed Germ Cell Tumours (MGCTs) of the testis are the second most common testicular tumours. In the 10 years retrospective study which was done on testicular neoplasms at our institute, this reported case accounted for 0.4%. We are presenting the case of a 30 year old male with a painless testicular swelling. Abdominal ultrasonography disclosed it as a seminoma and the FNAC report was Mixed Ger...

The clinical implications of the association between testicular microlithiasis (TM) and germ cell tumor (GCT) of the testis are still debated since the natural history of incidentally discovered TM has not been defined. Therefore, it is questionable whether TM can be considered as a precursor of malignancy. We are reporting the case of a 9-yr-old boy with a mixed GCT who had presented 3 yr earl...

retroperitoneal lymph node biopsy which revealed no evidence of malignancy, but detected 4–5 mm tumor necrosis foci in some areas. The patient followed by three cycles of chemotherapy with bleomycin, etoposide, and cisplatin protocol. Follow-up CT after chemotherapy revealed that the para-aortic lymphadenopathies had decreased in size to 3.4 cm × 2 cm × 1.6 cm. The patient then underwent a retr...

Mature teratoma comprises 5-10 % of all testicular neoplasms. Pure testicular teratoma is rare in adulthood with an incidence of 5 %. Regardless of differentiation postpubertal testicular teratoma have aggressive behavior and microscopic appearance of metastasis may differ from that of the primary. We present a case of pure teratoma of testis in an adult presenting as a metastatic germ cell tumor.

BACKGROUND Testicular cancer management is considered a marvel of modern science with excellent treatment results. Pakistan has a distinct ethnic variation and geographic distribution but data regarding clinical presentation of testicular tumors and their management is under reported. The objective of this study was to determine clinical profile, treatment modalities and survival outcome of tes...

BACKGROUND Late relapses of testicular germ cell tumor are uncommon. We report a case of cervical mature teratoma appeared 17 years after treatment of testicular teratocarcinoma. CASE PRESENTATION A 20-year-old patient underwent left sided orchiectomy followed by systemic therapy and retroperitoneal residual mass resection in 1989. He remained in complete remission for 200 months. In 2005 a h...

Hormone-sensitive lipase (HSL, Lipe, E.C.3.1.1.3) is a multifunctional fatty acyl esterase that is essential for male fertility and spermatogenesis and that also plays important roles in the function of adipocytes, pancreatic beta-cells, and adrenal cortical cells. Gene-targeted HSL-deficient (HSL-/-) male mice are infertile, have a 2-fold reduction in testicular mass, a 2-fold elevation of the...

testicular germ-cell tumors are the most common malignancy among men aged 20-40 years, and 60 percent of them are seminomas. these tumors are now an important socio-economic problem, considering their growing incidence. thus we undertook to evaluate the results of curative irradiation in our testicular seminoma patients and compare them to literature results considering the use of cobalt-60 sys...

OBJECTIVE To determine whether decreased testicular levels of enzymes necessary for retinoic acid biosynthesis were associated with male infertility, as retinoic acid is known to be necessary for spermatogenesis. DESIGN Observational analysis of testicular tissue samples, sperm indices, and serum hormone concentrations. SETTING Two infertility centers in Chile. PATIENT(S) 32 infertile men...