The testis though recognized as an immuneprivileged organ, there are a number of immunocompetent cells like macrophages, neutrophils and monocytes within the testicular interstitial compartment which give evidence of testicular immune response. Among them, macrophage population is the largest one and is known to influence the function of the neighboring Leydig cells. Testicular macrophages are ...

In conclusion, the information available indicates that the interactions between different cell types in the testis play an important role in the control and maintenance of testicular functions. Further characterization of these interactions will clearly provide insight into the cell biology of the testis and into the regulation of cellular differentiation, function, and growth. It is apparent ...

background: the availability of testis specific genes will be of help in choosing the most promising biomarkers for the detection of testicular sperm retrieval in patients with non-obstructive azoospermia (noa). testis specific chromodomain protein y 1 (cdy1) is a histone acetyltransferase which concentrates in the round spermatid nucleus, where histone hyperacetylation occurs and causes the re...

We determined the functional role of the Sertoli cell glucocorticoid receptor (GR) in vivo using a transgenic Cre-loxP approach to conditionally disrupt GR expression. Sertoli cell GR knockout (SCGRKO) was shown by absent Sertoli cell-specific GR immunolocalization and reduced levels of glucocorticoid-responsive Stc1 and Tsc22d3 mRNA in SCGRKO relative to control testes. Adult SCGRKO testes exh...

Sixty male patients of leprosy (mean age = 27.2 +/- 5.04 years) selected at random, were studied for gonadal involvement and therapeutic efficacy of two indigenous drugs. Of these 34 were married, with the mean duration of illness 4.17 +/- 3.27 years. Only those with lepromatous and dimorphous leprosy developed testicular and epididymal changes. Testicular pain and/or swelling (lepromatous = 62...

background: while young men are at higher risk of developing testicular cancer (tc), testicular-self examination (tse) is an easy, cost effectiveness method to early detection of this disease. the aim of the study was to investigate medical sciences student`s awareness, attitude and self-efficacy about tc and tse. methods: this cross-sectional study was carried out among full time young student...

The testicular capsule was studied histologically, morphometrically, ultrastructurally and immunohistochemically in the Japanese quail, domestic fowl, turkey and duck (all members of the Galloanserae). The testicular capsule was, relative to mammals, thin, being 81.5 +/- 13.7 microm in the quail, 91.7 +/- 6.2 microm in the domestic fowl, 104.5 +/- 29.8 microm in the turkey and 91.8 +/- 18.9 mic...

Although angiotensin II (Ang II) was reported to facilitate sperm motility and intratesticular sperm transport, recent findings shed light on the efficacy of Ang II in stimulating inflammatory events in testicular peritubular cells, effect of which may play a role in male infertility. It is still unknown whether Ang II can induce testicular apoptotic cell death, which may be a more direct actio...