نتایج جستجو برای: testes

تعداد نتایج: 10561  

2006
W. Keith Hoots Arly Nelson

The murine leukemia P388 is being evaluated as a potential model for testicular leukemia since this tumor is responsive to most of the drugs used to treat childhood acute lymphocytic leukemia. Infiltration of P388 cells into testes occurs, but the tumor cells plateau at about 10s to 106 cells/testes, a number inadequate to produce macroscopic disease. Therefore, disease could be evaluated only ...

Journal: :Journal of andrology 1999
C Wang A P Sinha Hikim Y H Lue A Leung S Baravarian R S Swerdloff

Reproductive aging in the male Brown Norway (BN) rat is characterized by decreased Leydig cell steroidogenesis associated with seminiferous tubule dysfunction. This could be a result of a combination of a primary testicular defect and a secondary hypothalamic pituitary dysfunction. In the present study, we determined in the BN rat whether germ cell loss occurred via apoptosis. We then defined t...

Journal: :American journal of physiology. Endocrinology and metabolism 2016
Rasmani Hazra Dannielle Upton Reena Desai Omar Noori Mark Jimenez David J Handelsman Charles M Allan

Recently, we created a unique gain-of-function mouse model with Sertoli cell-specific transgenic androgen receptor expression (TgSCAR) showing that SCAR activity controls the synchronized postnatal development of somatic Sertoli and Leydig cells and meiotic-postmeiotic germ cells. Moderate TgSCAR (TgSCAR(m)) expression reduced testis size but had no effect on male fertility. Here, we reveal tha...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Jana Koubova Douglas B Menke Qing Zhou Blanche Capel Michael D Griswold David C Page

In mammals, meiosis is initiated at different time points in males and females, but the mechanism underlying this difference is unknown. Female germ cells begin meiosis during embryogenesis. In males, embryonic germ cells undergo G0/G1 mitotic cell cycle arrest, and meiosis begins after birth. In mice, the Stimulated by Retinoic Acid Gene 8 (Stra8) has been found to be required for the transiti...

2014
Henrique Prado Sousa André Luiz de Castro Leal Arndt von Staa Julio Cesar Sampaio do Prado Leite

Resumo. A modelagem de processos de negócio é um recurso que vem sendo empregado com diversas finalidades, entre as quais, planejamento e alinhamento estratégico. Na engenharia de requisitos, os modelos de processos de negócio também são utilizados como insumos na extração de requisitos de software, os quais deverão ser utilizados com base para testes posteriores. Neste sentido, propomos um mét...

2016
Mahua Rudra Min Bahadur

Lactate dehydrogenase (LDH) isozyme study in the liver, kidney and testes of Mus terricolor, an indigenous species of India, revealed the presence of a slow migrating variant of LDH isozyme, LDH-C4 along with other five usual LDH isozymes present in other tissues. The synthesis of LDH-C4 is controlled by a separate locus Ldh c. The results have shown differential expression of LDH-C4 and LDH-A4...

2012
Ahmed E. Abdel Moniem Mohamed A. Dkhil Saleh Al-Quraishy

Even though the toxic effects of lead compounds had been studied over many years, inconsistent results have been obtained about their oxidative stress in the testes of adult rats. Lead acetate (20 mg/kg) alters the histology of testes as well as enhances lipid peroxidation and nitric oxide production in both serum and testes with concomitant reduction in glutathione (GSH) and antioxidant enzyme...

Journal: :The Journal of veterinary medical science 2006
Phil-Ok Koh Chung-Kil Won

The present study was designed to evaluate the effect of ethanol on pituitary adenylate cyclase activating polypeptide (PACAP) and its typ I (PAC1) receptor expression in adult rat testes. Ethanol (3 g/kg i.p., 15% v/v in saline) was administrated to adult male rats for 10 days. Using northern blot analysis, the present study showed the reduction of PACAP mRNA levels in rat testes by ethanol ad...

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