نتایج جستجو برای: testes
تعداد نتایج: 10561 فیلتر نتایج به سال:
The murine leukemia P388 is being evaluated as a potential model for testicular leukemia since this tumor is responsive to most of the drugs used to treat childhood acute lymphocytic leukemia. Infiltration of P388 cells into testes occurs, but the tumor cells plateau at about 10s to 106 cells/testes, a number inadequate to produce macroscopic disease. Therefore, disease could be evaluated only ...
Reproductive aging in the male Brown Norway (BN) rat is characterized by decreased Leydig cell steroidogenesis associated with seminiferous tubule dysfunction. This could be a result of a combination of a primary testicular defect and a secondary hypothalamic pituitary dysfunction. In the present study, we determined in the BN rat whether germ cell loss occurred via apoptosis. We then defined t...
Recently, we created a unique gain-of-function mouse model with Sertoli cell-specific transgenic androgen receptor expression (TgSCAR) showing that SCAR activity controls the synchronized postnatal development of somatic Sertoli and Leydig cells and meiotic-postmeiotic germ cells. Moderate TgSCAR (TgSCAR(m)) expression reduced testis size but had no effect on male fertility. Here, we reveal tha...
In mammals, meiosis is initiated at different time points in males and females, but the mechanism underlying this difference is unknown. Female germ cells begin meiosis during embryogenesis. In males, embryonic germ cells undergo G0/G1 mitotic cell cycle arrest, and meiosis begins after birth. In mice, the Stimulated by Retinoic Acid Gene 8 (Stra8) has been found to be required for the transiti...
Resumo. A modelagem de processos de negócio é um recurso que vem sendo empregado com diversas finalidades, entre as quais, planejamento e alinhamento estratégico. Na engenharia de requisitos, os modelos de processos de negócio também são utilizados como insumos na extração de requisitos de software, os quais deverão ser utilizados com base para testes posteriores. Neste sentido, propomos um mét...
Lactate dehydrogenase (LDH) isozyme study in the liver, kidney and testes of Mus terricolor, an indigenous species of India, revealed the presence of a slow migrating variant of LDH isozyme, LDH-C4 along with other five usual LDH isozymes present in other tissues. The synthesis of LDH-C4 is controlled by a separate locus Ldh c. The results have shown differential expression of LDH-C4 and LDH-A4...
Even though the toxic effects of lead compounds had been studied over many years, inconsistent results have been obtained about their oxidative stress in the testes of adult rats. Lead acetate (20 mg/kg) alters the histology of testes as well as enhances lipid peroxidation and nitric oxide production in both serum and testes with concomitant reduction in glutathione (GSH) and antioxidant enzyme...
The present study was designed to evaluate the effect of ethanol on pituitary adenylate cyclase activating polypeptide (PACAP) and its typ I (PAC1) receptor expression in adult rat testes. Ethanol (3 g/kg i.p., 15% v/v in saline) was administrated to adult male rats for 10 days. Using northern blot analysis, the present study showed the reduction of PACAP mRNA levels in rat testes by ethanol ad...
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