Hexavalent chromium Cr (VI) used in shielded metal arc welding is widely recognized to act as a carcinogen, mutagen and teratogen. The carcinogenic potential of metals is a major issue in defining human health risk from exposure. Hence in the present investigation, 66 welders and 60 control subjects with similar mean ages, smoking prevalences and alcohol consumption were enrolled for DNA damage...

Lymphocytic choriomeningitis virus (LCMV) is an underdiagnosed fetal teratogen. This diagnosis should be considered for infants and children with unexplained hydrocephalus, micro- or macrocephaly, intracranial calcifications, chorioretinitis, and nonimmune hydrops. The immunofluorescent antibody test is the only reasonable, commercially available, screening diagnostic tool. The differential dia...

Forty years ago, alcohol was not commonly recognized as a teratogen, an agent that can disrupt the development of a fetus. Today, we understand that prenatal alcohol exposure induces a variety of adverse effects on physical, neurological, and behavioral development. Research supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) has contributed to the identification of the ...

Our experimental findings show that succinate and ascorbate greatly reduce the teratogenic effects of 3-acetylpyridine, 6-aminonicotinamide and sulfanilamide. Glycerophosphate led to similar alleviating results when used in combination with 3-acetylpyridine and 6-aminonicotinamide, but not with sulfanilamide. With certain other teratogens the high-energy intermediates failed to alleviate; in so...

Cadmium Chloride is a well known teratogen compared to other metals. Cadmium affects placental function, may cross the placental barrier and modify fetal development. In this study, 12 female wistar albino rats weighted between 180-200gr were used. They were divided into two groups as experimental and control groups each comprising 6 female animals. 2mg/kg/day cadmium chloride dissolved in 1ml ...

QUESTION One of my female patients has epilepsy and is currently receiving lamotrigine monotherapy. She has recently found that she is 6 weeks pregnant and is concerned about possible side effects of lamotrigine on her fetus. How should I advise her and should I switch to another antiepileptic drug? ANSWER Lamotrigine (LTG) has not been associated with an increased risk for major malformation...

On Thursday, 16 June, 2011 a two months old male Kano brown goat was presented to the Niger State Veterinary Hospital, Bosso-Minna with multiple facial abnormalities. History revealed that the flock did not have antecedents of malformations or apparent reasons that induced the abnormalities. Phenotypical examination revealed that the goat could have been under the influence of some teratogen or...

Alcohol is a potent teratogen to the developing CNS, and moderate-heavy alcohol intake during pregnancy causes fetal alcohol syndrome (FAS) and fetal alcohol spectrum disorder (FASD). These patients display CNS symptoms associated with developmental deficits, cognitive impairment and social abnormalities, with structural impairments in several brain regions. In this dissertation, we investigate...

Abstract 
 Aim: Our aim is to investigate Hypoplastic Left Heart Syndrome diagnosed pregnancies that were followed up in Tepecik Education and Research Hospital- Perinatology Unit between 2015-2020, retrospectively. Matherials Methods: The archieves scanned Maternal features such as age, gravidy, parity, teratogen exposure, concominant disease existence, karyotyping rejection decision for ...