Our understanding of the pathogenesis of "tendinopathy" is based on fragmented evidences like pieces of a jigsaw puzzle. We propose a "failed healing theory" to knit these fragments together, which can explain previous observations. We also propose that albeit "overuse injury" and other insidious "micro trauma" may well be primary triggers of the process, "tendinopathy" is not an "overuse injur...

Surgical treatment for tendon injuries can be done using several repair techniques, but they always involve placement of suture material. The arrangement of the suture needs to maintain the apposition of the tendon stumps, preferably under conditions of movement. During the healing process, the suture thread should cause minimal tissue reaction and should have sufficient resistance to traction ...

Injury to muscle and tendon structures can substantially affect individual joint mobility and stability. Furthermore, muscle and tendon injuries can alter movement of the entire body and ultimately limit functional participation in life activities. The goal of this chapter is to aid the clinician in identifying and treating muscle and tendon injuries. Specifically, the objectives of this chapte...

Management of tendinopathies and tendon rupture is challenging. In the last few decades, several emerging strategies including tissue engineering with mesenchymal stem cells have been proposed to enhance tendon healing. They hold the promise to yield more successful outcomes for the management of patients with tendon pathology. Current in vitro studies support the application of these cell-base...

PREFACE 3 Preface It is indeed a pleasure to present our report of research activities 2001-2002. We thank you for your interest and your support during the last two years. We hope that this information is of use to you and look forward to continuing what has become excellent cooperation. Biomechanical analysis of biodegradable interbody fusion cages augmented with Poly(propylene glycol-co-fuma...

Background. Earlier studies have reported positive results from eccentric training in patients with tendon disorders. The reasons for the benefi cial clinical effects of eccentric training are not known. Vascularization followed by regression of the vasculature enhances the healing response of injured tendons. Eccentric exercise induces a more benefi cial healing response than concentric exerci...

BACKGROUND Earlier studies have reported positive results from eccentric training in patients with tendon disorders. The reasons for the beneficial clinical effects of eccentric training are not known. Vascularization followed by regression of the vasculature enhances the healing response of injured tendons. Eccentric exercise induces a more beneficial healing response than concentric exercise....

BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawle...

Since tendon injuries and tendinopathy are a growing problem, sometimes requiring surgery, new strategies that improve conservative therapies are needed. Platelet-rich plasma (PRP) seems to be a good candidate by virtue of its high content of growth factors, most of which are involved in tendon healing. This study aimed to evaluate if different concentrations of platelets in PRP have different ...

UNLABELLED Bromelain, an enzyme extracted from the stem of the pineapple plant has been proposed as a treatment for reducing pain and swelling following acute muscle injuries but studies are yet to be done on its effect on tendon healing. This study therefore investigated the effects of bromelain on tenocyte proliferation and the tendon malondialdehyde (MDA) level in the early stage of healing ...