Programmable DNA-binding polyamides coupled to short peptides have led to the creation of synthetic artificial transcription factors. A hairpin polyamide-YPWM tetrapeptide conjugate facilitates the binding of a natural transcription factor Exd to an adjacent DNA site. Such small molecules function as protein-DNA dimerizers that stabilize complexes at composite DNA binding sites. Here we investi...

Abbreviations: Ab, antibody; ALP, alkaline phospha atrazine conjugated with horseradish peroxidase; CE, c nanotubes; CV, cyclic voltammetry; ELISA, enzyme-linke high-density polyethylene; HRP, horseradish peroxid magnetic beads; NP, nanoparticle; PAP, p-aminoph phosphate; PET, polyethylene terephthalate; POC, point electrode; RT, room temperature; TMB, 3,3′,5,5′-tetramet tetramethylbenzidine di...

BACKGROUND Subclinical hypothyroidism itself is associated with serious complications and also there is a known risk of subclinical hypothyroidism patients getting converted into overt disease. OBJECTIVES The objective of the present study was to fi nd out the prevalence of subclinical hypothyroidism in the suspected cases i.e. amongst the cases attending the thyroid laboratory at B.P. Koiral...

Serum TSH measurement is the most sensitive screening test for thyroid dysfunction and for the diagnosis of subtle forms of hyperand hypothyroidism (1). Serum TSH has a loglinear relationship with circulating thyroid hormone levels; thus a small change in peripheral thyroid hormone concentrations, even within the normal laboratory reference range, may result in an increase or decrease in serum ...

BACKGROUND Widespread use of automated sensitive assays for thyroid hormones and thyroid-stimulating hormone (TSH) has increased identification of mild thyroid dysfunction, especially in elderly patients. The clinical significance of this dysfunction, however, remains uncertain, and associations with cognitive impairment, depression, and anxiety are unconfirmed. OBJECTIVE To determine the ass...