OBJECTIVE Tardive dyskinesia (TD) is the principal adverse effect of long-term treatment with conventional antipsychotic agents. Several mechanisms may exist for this phenomenon. Mechanisms for the lower incidence of TD with atypical antipsychotics also remain to be fully understood. We undertook to explore and better understand these mechanisms. METHODS We conducted a comprehensive review of...

Tourette Disorder (TD) is a childhood-onset neuropsychiatric and neurodevelopmental disorder characterized by the presence of both motor and vocal tics. The genetic architecture of TD is believed to be complex and heterogeneous. Nevertheless, DNA sequence variants co-segregating with TD phenotypes within multiplex families have been identified. This report examines whole exomes of affected and ...

The purpose of this article is to summarize and integrate the articles appearing in this special issue within the unique technology development (TD) and human resources (HR) of Southeast Asian countries. This paper examines how the synergy between TD and HR can lead to improved national economic performance. We proposed that better HR exploitation can sustain the capabilities of TD. Thus, the d...

Transient afterdepolarizations (TD) were analyzed following a train of paced action potentials in isolated pectinate muscles bordering the crista terminalis in rabbit right atria. After cessation of a rapid drive TD peaked between 400 and 700 ms. The amplitude of TD were found to be pacing-dependent (maximum at 250 ms pre-drive pacing interval 12.9 +/- 2.2 mV, n = 27). At pacing intervals longe...

We studied whether movements associated with tardive dyskinesia (TD) served operant functions in 2 men with developmental disabilities. We found that TD-related movements occurred more frequently in the alone and attention conditions and less frequently in control and demand conditions. Our findings suggest that TD-related movements may not be maintained by social reinforcers and that decreases...

OBJECTIVE To evaluate differences in the initial prognosis of patients with cutaneous melanoma managed by teledermatology (TD) vs other non-TD referral systems. DESIGN Descriptive and longitudinal study of a store-and-forward TD system aimed at the triage of patients with suspicious pigmented lesions. SETTING In 2003, a store-and-forward TD triage system aimed at the selection of patients w...

TD-FALCON is a self-organizing neural network that incorporates Temporal Difference (TD) methods for reinforcement learning. Despite the advantages of fast and stable learning, TD-FALCON still relies on an iterative process to evaluate each available action in a decision cycle. To remove this deficiency, this paper presents a direct code access procedure whereby TD-FALCON conducts instantaneous...

Objectives: Accurate diagnosis of Persian children with Developmental Language Disorder (DLD) is regarded as a challenge for Speech and Language Pathologists (SLPs) in Iran because of the lack of formal linguistic tests that can reliably distinguish language-impaired children from Typically-Developing (TD) children. This study aimed to investigate the diagnostic accuracy of the photographic exp...

BACKGROUND The regulatory molecule for cell life span, telomerase, was modified by human telomerase reverse transcriptase (hTERT) gene transfer to investigate its effect on regenerative properties of endothelial progenitor cells (EPCs) in neovascularization. METHODS AND RESULTS Telomerase activity was enhanced in hTERT-transduced EPCs (Td-TERTs) (1.2-fold versus no transduced EPCs [no-Td] and...

24 Teledermatology (TD) is an emerging modality for providing remote dermatologic care with high diagnostic and management 25 concordance compared to face-to-face clinic dermatology. TD training among dermatology residency programs in the United 26 States has not been characterized. We disseminated a survey to all dermatology residents at ACGME accredited programs in the 27 United States to exp...