نتایج جستجو برای: tcr

تعداد نتایج: 12834  

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2001
K C Garcia C G Radu J Ho R J Ober E S Ward

In the current study, cellular and molecular approaches have been used to analyze the biophysical nature of T cell receptor (TCR)-peptide MHC (pMHC) interactions for two autoreactive TCRs. These two TCRs recognize the N-terminal epitope of myelin basic protein (MBP1-11) bound to the MHC class II protein, I-A(u), and are associated with murine experimental autoimmune encephalomyelitis. Mice tran...

Journal: :Blood 1995
E Goulmy J Pool P J van den Elsen

Minor histocompatibility antigens (mHags) are involved in the induction of graft-versus-host disease (GVHD) after HLA-identical bone marrow transplantation. Previously, we isolated a series of HLA-A*0201-restricted cytotoxic T-cell (CTL) clones specific for the same mHag HA-1 from peripheral blood of three unrelated patients who were suffering from GVHD. We have now analyzed the composition of ...

Journal: :Journal of immunology 2008
Moniek A de Witte Annelies Jorritsma Andrew Kaiser Marly D van den Boom Maarten Dokter Gavin M Bendle John B A G Haanen Ton N M Schumacher

Adoptive transfer of TCR gene-modified T cells has been proposed as an attractive approach to target tumors for which it is difficult or impossible to induce strong tumor-specific T cell responses by vaccination. Whereas the feasibility of generating tumor Ag-specific T cells by gene transfer has been demonstrated, the factors that determine the in vivo effectiveness of TCR-modified T cells are...

2012
Rangsima Reantragoon Lars Kjer-Nielsen Onisha Patel Zhenjun Chen Patricia T. Illing Mugdha Bhati Lyudmila Kostenko Mandvi Bharadwaj Bronwyn Meehan Ted H. Hansen Dale I. Godfrey Jamie Rossjohn James McCluskey

Mucosal-associated invariant T (MAIT) cells express a semiinvariant αβ T cell receptor (TCR) that binds MHC class I-like molecule (MR1). However, the molecular basis for MAIT TCR recognition by MR1 is unknown. In this study, we present the crystal structure of a human Vα7.2Jα33-Vβ2 MAIT TCR. Mutagenesis revealed highly conserved requirements for the MAIT TCR-MR1 interaction across different hum...

Journal: :Cancer research 2000
C P Wong R Levy

Vaccination using recombinant tumor-derived T-cell antigen receptor (TCR) protein induces a protective, idiotype-specific immune response against a murine T-cell tumor. However, the technically demanding task of producing patient-specific, recombinant TCR protein restricts the translation of TCR vaccines for clinical use. We report here the development of an effective recombinant TCR adenovirus...

Journal: :The Journal of Experimental Medicine 2002
Maddalena Panigada Simona Porcellini Eliane Barbier Sonja Hoeflinger Pierre-André Cazenave Hua Gu Hamid Band Harald von Boehmer Fabio Grassi

The pre-T cell receptor (TCR) signals constitutively in the absence of putative ligands on thymic stroma and signal transduction correlates with translocation of the pre-TCR into glycolipid-enriched microdomains (rafts) in the plasma membrane. Here, we show that the pre-TCR is constitutively routed to lysosomes after reaching the cell surface. The cell-autonomous down-regulation of the pre-TCR ...

Journal: :The Journal of Experimental Medicine 1998
Hala S. Azzam Alex Grinberg Kin Lui Howard Shen Elizabeth W. Shores Paul E. Love

Recent data indicate that the cell surface glycoprotein CD5 functions as a negative regulator of T cell receptor (TCR)-mediated signaling. In this study, we examined the regulation of CD5 surface expression during normal thymocyte ontogeny and in mice with developmental and/or signal transduction defects. The results demonstrate that low level expression of CD5 on CD4(-)CD8(-) (double negative,...

Journal: :Journal of immunology 2004
Mihiri De Silva-Udawatta Senthil R Kumar Eric L Greidinger Robert W Hoffman

There is increasing evidence that the TCR can have significant plasticity in the range of Ags that a single receptor can recognize. Although it has been proposed that such TCR plasticity might contribute to autoimmunity, there have been few studies examining this possibility in either animal models or human disease. In the present study, we examined human T cell clones that were generated again...

Journal: :The Journal of Experimental Medicine 2003
Abdelbasset Hamrouni Anne Aublin Philippe Guillaume Janet L. Maryanski

Due to ordered, stage-specific T cell receptor (TCR)-beta and -alpha locus gene rearrangements and cell division during T cell development, a given, ancestral TCR-beta locus VDJ rearrangement might be selected into the mature T cell repertoire as a small cohort of "half-sibling" progeny expressing identical TCR-beta chains paired with different TCR-alpha chains. The low frequency of such a coho...

Journal: :Experimental animals 2009
Kazutaka Kitaura Kiichi Kanayama Yoshiki Fujii Noriyuki Shiobara Konagi Tanaka Ichiro Kurane Satsuki Suzuki Tsunetoshi Itoh Ryuji Suzuki

Diversity in T cell recognition of antigens is determined by diverse usage of T cell receptor (TCR) repertoire. TCR repertoire analysis provides fundamental information for understanding T cell immune responses in the pathogenesis of various diseases. In the present study, we examined the TCR repertoire in various tissues in normal BALB/c mice. The TCR alpha chain variable region repertoires we...

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