نتایج جستجو برای: tcells
تعداد نتایج: 170 فیلتر نتایج به سال:
What is the role of bacterial exposure in asthma protection and prevention? This topic is receiving increasing attention, particularly based on epidemiological findings relating to the ‘hygiene hypothesis’. More than a decade ago the observation was made that infants living in a microbial-rich environment show a high degree of protection, particularly against respiratory allergies and allergic ...
Type 1 diabetes (T1D), an insulin-dependent diabetes, is considered to be an autoimmune disease. The cause of T1D is the destruction of insulin-producing cells in the pancreatic islets and thus lifelong insulin treatment is necessary. The pancreatic islets are infiltrated with the cells of the immune system and the destruction is considered to be T-cell-mediated. The autoimmune nature of T1D is...
Type 1 diabetes is conventionally thought to result from T-cell–mediated autoimmune destruction of pancreatic -cells (1–3). Experimental and clinical evidence accumulated over the past two decades indicates that T-cells play a critical role in the pathogenesis of type 1 diabetes in both humans and the nonobese diabetic (NOD) mouse model of this disease (4). Indeed, the important contribution of...
Allergic asthma is usually diagnosed on the basis of the medical history, recurrent airway obstruction, bronchial hyperresponsiveness and the presence of an underlying allergic diathesis as assessed by skin provocation, variably increased eosinophil numbers in the blood and sputum, and the detection of allergen-specific immunoglobulin E (IgE). Based on the above criteria many cases of asthma ca...
In this study, immunotoxins containing monoclonal anti-human T-cell leukemia antibodies are shown to be capable of specific killing of human T-leukemia cells in vitro. These immunotoxins were prepared by conjugating ricin A chain (RIA) with our recently generated murine monoclonal anti bodies, SN1 and SN2, the latter of which was obtained from a hybridoma clone N6/D11 described previously by Ne...
Marathon running is a stressful event that can significantly affect virtually any of the physiologic systems of a runner. The goal of this study was to investigate effects of marathon running on human immune and neuroendocrine parameters and their interaction. Blood samples were collected from 15 male runners (38.3 ± 6.9 years) 18 hours before finish time, then within 20 minutes (0h), 1 hour, 2...
VITAMIN D: A TRUE ENDOGENOUS IMMUNOMODULATOR Recently, vitamin D has received increased worldwide attention for its involvement in reducing risk for several chronic diseases including many cancers, infectious diseases, type 1 diabetes and notably autoimmune rheumatic diseases. The final active metabolite of vitamin D (1,25(OH)D3) is considered a steroid hormone for its origin from cholesterol (...
Background: Little is known about the biology of meniscal allograft transplantation in humans. In particular, little information is available about the phenotype of the cells that repopulate the allograft, whether an immune response is elicited against the graft, and whether the repopulating cells synthesize normal extracellular matrix components. Methods: A small biopsy specimen of the menisca...
Recent insights into immune system function have fostered a better appreciation of the role of specialized antigen-presenting cells (i.e., dendritic cells). Initially described by Steinman and Cohn (1) in 1973 as an adherent cell type among mouse splenocytes with a distinctive stellate morphology, dendritic cells soon became known for their role as the sentinels of the immune system (2). In the...
Atherosclerosis is recognized as a chronic inflammatory process that accelerates in the context of high cholesterol levels. The unique aspect of atherosclerosis, over other inflammatory diseases, is the major effect of the cholesterol environment. There is accumulating evidence that lipids can influence inflammatory responses and vice versa, but so far the lipid and inflammatory components that...
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