نتایج جستجو برای: tb104 و ag85b
تعداد نتایج: 760814 فیلتر نتایج به سال:
BACKGROUND Newborns display distinct immune responses, leaving them vulnerable to infections and impairing immunization. Targeting newborn dendritic cells (DCs), which integrate vaccine signals into adaptive immune responses, might enable development of age-specific vaccine formulations to overcome suboptimal immunization. OBJECTIVE Small-molecule imidazoquinoline Toll-like receptor (TLR) 8 a...
Targeting dendritic cells in vivo by transcutaneous peptide immunization (TCI) represents an efficient immunization strategy to induce tumor-specific CTL because it reflects the physiologic conditions occurring during pathogen infection. Here we show that including a Th1 peptide in TCI can activate preexisting memory Th1 (mTh1) responses and thereby enhance the CTL response. For this purpose, p...
زۆربەى لێکۆڵينەوەکان کە لە سەر ناوچەى ئاکرێ نووسراون زیاتر لایەنەکانى سیاسى و کارگێڕى سەربازى دەگرێتەوە, کاتێکدا بوارە گرنگەکانى ديكه‌ى ژیان فەرامۆش کراون، بە تایبەتى لایەنى ئابوورى نێویشيدا بوارى کشتوکاڵ زەورى زار، پەیوەندى راستەوخۆى لەگەڵ ژیانى مروڤدا هەیە, سەرەڕاى ئەمەش لەچاو کەمتر بایەخى پێ دراوە, بۆیە پێمان باش بوو لەسەر ئەم بابەتە بنووسين. ئامانجى سەرەکیشمان ئەوەیە بەم لێکۆڵینەوە لایەنێکى...
* ايجولونكت دهعم – دادغب , ينقتلا ميلعتلا ةئيه / دادغب ** مسق ةسدنه نداعملاو جاتنلاا , ةيجولونكتلا ةعماجلا / دادغب *** ايجولونكتلاو مولعلا ةرازو / دادغب 497 مييقت لكآتلا ةمواقم طاسوا يف ةيتيركنوكلا ةناسرخلا ةيوقت يف مدختسملا ديدحلل ةفلتخم ةيئام بوقعي فسوي ثيل * شابك ةرهزلا دبع لحز ** و حلاص دمحم قفوم *** 2010/12/21 خیرات میدقتلا : 2011/6/2 خیرات لوبقلا : ةصلاخلا ف حيلستلا ديدحل ...
Background & Aims: Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remain as a leading causes of mortality among infectious diseases. The only current vaccine, bacillus Calmette-Gue´rin (BCG), displays highly variable efficiency for preventing tuberculosis. Thus, identification of protective antigens could be mentioned for designing new vaccines. Among different Mtb antigens,...
Many epidemiological studies have suggested that the recent increase in prevalence and severity of allergic diseases such as asthma is inversely correlated with Mycobacterium bovis bacillus Calmette Guerin (BCG) vaccination. However, the underlying mechanisms by which mycobacterial components suppress allergic diseases are not yet fully understood. Here we showed the inhibitory mechanisms for d...
The recombinant fusion proteins hybrid 1 [H1 (Ag85B-ESAT-6)] and hybrid 56 [H56 (Ag85B-ESAT-6-Rv2660c)] derived from Mycobacterium tuberculosis are promising antigens for subunit vaccines against tuberculosis. Both antigens are early batches of antigens to be enrolled in human clinical trials and it is therefore important to characterize their conformational stability in solution as well as upo...
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