BACKGROUND Recently, the tuberculosis (TB) Task Force Impact Measurement acknowledged the need to review the assumptions underlying the TB mortality estimates published annually by the World Health Organization (WHO). TB mortality is indirectly measured by multiplying estimated TB incidence with estimated case fatality ratio (CFR). We conducted a meta-analysis to estimate the TB case fatality r...

background cigarettes smoking is a risk factor for tuberculosis (tb). associations between smoking and tb disease have been reported, but there are few reports on the influence of smoking on the sputum smear and culture conversion time. this study surveyed the possible association between smoking and sputum smear conversion time among new smear-positive pulmonary tuberculosis patients. patients...

background vitamin d (vit d) level may change variously in serums of patients undergoing anti-tuberculosis (anti-tb) therapy using antibiotics such as isoniazid and rifampin. objectives the current study aimed to evaluate all components of calcium (ca) regulatory agents in the six- month period of standard anti- tb therapy. patients and methods eight adults whose pulmonary tb had been diagnosed...

BACKGROUND Information on treatment outcomes among hospitalized patients with multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) are scarce in China. METHODOLOGY/PRINCIPAL FINDINGS We conducted this retrospective study to analyze the characteristics and treatment outcomes in MDR- and XDR-TB patients in the 309 Hospital in Beijing, China during 1996-...

OBJECTIVES To determine the proportion of patients developing active tuberculosis (TB) versus that of patients who experience worsening of TB, after initiating highly active anti retroviral therapy (HAART). METHODS Charts of HAART naïve patients with or without clinically active TB who consecutively commenced HAART at Mulago Hospital Infectious Diseases Institute were reviewed. Patients were ...

BACKGROUND HIV/TB coinfection remains a major challenge even after the initiation of HAART. Little is known about Mycobacterium tuberculosis (Mtb) specific immune restoration in relation to immunologic and virologic outcomes after long-term HAART during co-infections with latent and active TB. METHODS A total of 232 adults, including 59 HIV patients with clinical TB (HIV + TB+), 125 HIV patie...

Introduction: Every year millions of people fall sick with Tuberculosis (TB). Multidrug-resistant tuberculosis (MDR-TB) has a life threatening public health crisis globally. Objective: To determine the successful treatment outcomes MDR-TB in Bangladeshi population. Methods: This retrospective cohort study was conducted at National Institute Diseases Chest and Hospital (NIDCH) Mohakhali, Dhaka, ...

Most cases of adult-onset tuberculosis (TB) result from reactivation of a pre-existing Mycobacterium tuberculosis infection. Mycobacterium tuberculosis usually invades the respiratory tract and most patients develop intrapulmonary TB; however, some patients develop concurrent pulmonary and extra-pulmonary TB. The purpose of the present study was to identify the demographic and clinical factors ...

BACKGROUND Collaborative TB/HIV management is essential to ensure that HIV positive TB patients are identified and treated appropriately, and to prevent tuberculosis (TB) in HIV positive patients. The purpose of this study was to assess HIV case finding among TB patients and Co-trimoxazole Preventive Therapy (CPT) for HIV/TB patients in Addis Ababa. METHODS A descriptive cross-sectional, faci...

BACKGROUND Tuberculosis (TB) and human immune virus/acquired immune deficiency syndrome (HIV/AIDS) stigmas affect public attitudes toward TB treatment and policy. This study examined 'stigmatizing' ideas and the view that 'TB patients should line-up in the chronic illness queue' in relation to preferences and attitudes toward TB treatment. METHODS Data were gathered through a survey administe...