نتایج جستجو برای: tail flick test

تعداد نتایج: 858539  

Journal: :African journal of traditional, complementary, and alternative medicines : AJTCAM 2014
Lamees Ben Saad Kim Kah Hwi Tony Quah

BACKGROUND There are severe adverse effects of analgesic drugs on human body. Extraction of analgesic drugs from natural products has therefore become the prime objective of the study. In this study, we aimed to evaluate the antinociceptive activity of the pomegranate fruit. MATERIALS AND METHODS Antinociceptive activity of ethanol pomegranate extract was examined using three models of pain: ...

Journal: :medical journal of islamic republic of iran 0
s semnanlan from the department of physiology, shaheed beheshti university of medical sciences, tehran, islamicrepublic of iran. m dashti

bulbospinal noradrenergic pathways are shown to have an important role in descending inhibition of pain sensation. locus ceruleus (lc), as a rich noradrenergic nucleus in the brain stem which has projections into the dorsal horn of the spinal cord, was evaluated for antinociceptive activity by using tonic and phasic pain models in the rat. lc-lesioned rats demonstrated moderate increase in both...

ژورنال: :مجله دانشگاه علوم پزشکی مازندران 0
فاطمه حجی پور fatemeh hajipoor msc student in animal physiology, faculty of sciences, ferdowsi university of mashhad, mashhad, iranعلوم پزشکی مازندران مسعود فریدونی masoud fereidoni associate professor, applied research center for neurofeedback and neurobehavioral sciences, department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, iranمشهد: خراسان رضوی، مشهد، دانشگاه فردوسی مشهد، دانشکده علوم، گروه زیست شناسی، مرکز پژوهش های کاربردی نوروفیدبک، علوم اعصاب و رفتار علی مقیمی ali moghimi professor, applied research center for neurofeedback and neurobehavioral sciences, department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, iranعلوم پزشکی مازندران

سابقه و هدف: ویتامین k2 از مشتقات ویتامین k و محلول در چربی است. این ویتامین به دلیل توانایی عبور از سد خونی- مغزی با مقادیر فراوانی در مغز حضور دارد. سایر مشتقات ویتامین k برای حضور در مغز باید به فرم k2 تبدیل شوند که نشان دهنده اهمیت آن در سیستم عصبی است. شواهدی مبنی بر اثرات ضد دردی ویتامین k2 وجود دارد. بررسی اثرات تجویز نخاعی آن بر درد طی آزمون tail-flick و فرمالین، هدف این مطالعه می باشد....

2013
Zafar Ahmad Malik Nahida Tabassum Pyare Lal Sharma

Momordica Charantia (MC) is one of the most famous traditional plant worldwide, used for the treatment of diabetes and its complications. In the present study possible protective effect of MC in Streptozotocin (STZ) induced diabetic neuropathy in mice was evaluated. STZ induced diabetic mice were orally administered MC at various doses (200 800 mg/kg) for six weeks. Diabetes induced neuropathic...

Journal: :research in pharmaceutical sciences 0
v. hajhashemi a. ghannadi s. sedighifar

extracts obtained from the aerial parts of stachys lavandulifolia (lamiaceae) are used in iranian folk medicine as remedies for the treatment of various painful and inflammatory diseases. for evaluation of its probable analgesic and anti-inflammatory effects, hydroalcoholic, polyphenolic and boiled extracts of the aerial parts of the herb were prepared and their analgesic effects were studied i...

2017
Xiaoyu Pan Jiechun Chen Weijie Wang Ling Chen Lin Wang Quan Ma Jianbo Zhang Lichao Chen Gang Wang Meixi Zhang Hao Wu Ruochuan Cheng

Resveratrol has been widely investigated for its potential health properties, although little is known about its mechanism in vivo. Previous studies have indicated that resveratrol produces antinociceptive effects in mice. Calcium channels and calcium/caffeine-sensitive pools are reported to be associated with analgesic effect. The present study was to explore the involvement of Ca2+ channel an...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
S N Thorat D L Hammond

In this study, we characterized the role of delta-1 and delta-2 opioid receptors in the ventromedial medulla (VMM) in the modulation of thermal nociception. Male Sprague-Dawley rats were prepared with an intracerebral guide cannula aimed at the nucleus raphe magnus or nucleus reticularis gigantocellularis pars alpha. Microinjection of the delta-1 opioid receptor agonist [D-Pen2,D-Pen5]enkephali...

2015
Radhakrishnan Mahesh Shruti Viyogi Dilip Kumar Pandey Sushil Yadav

Although a clinical connection between pain and depression has long been recognized, how these two conditions interact remains unclear. Here we report the comorbidity of pain and depression-like behavior. The antidepressant and analgesic like activity of Ondansetron (OND, 0.25-2mg/kg) were investigated in animal models of acute depression (forced swim test ) and pain ( tail flick test) , existe...

A Sarihi B Heshmatian

Recent neuroanatomical and behavioral evidence has indicated that vasopressin (VA) increases pain threshold. The dorsal raphe nucleus (DRN) is an important nucleus in pain modulation. Anatomical studies have shown that DRN receives vasopressinergic fibers originating in the hypothalamic paraventricular nucleus. The aim of the present study was to examine the effects of intra-DRN injection of de...

Journal: :Hippokratia 2015
M G Turtay M Karabas H Parlakpinar C Colak M Sagir

BACKGROUND Apelin has various effects on a lot of systems such as central nervous system and cardiovascular system. This study investigated the possible analgesic effects of apelin-13 using the hot-plate and the tail-flick thermal analgesia tests in rats. We also evaluated the mechanism underlying the analgesic effects of apelin-13 by pretreating with Nw-nitro-L-arginine methyl ester (L-NAME) o...

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