This research was performed to analyze the antinociceptive task of methanolic extract Ipomoea marginata in addition silico evaluation separated constituents from versus cyclooxygenase 2 enzyme together with absorption, distribution, metabolism, excretion/toxicity analysis substances. In vivo examined by acetic acid-induced agonizing, tail immersion and hot plate on rodents. activity isolated su...

in today’s competitive word, it is so important to offer a new way in the cycle of production and supply by which the maximum efficiency will be achieved. the problem of applying cross-docking operations in logistics and supply chain network design, as a new and applicable approach, has attracted much attention in both academic and industrial areas. the matter making this strategy be highly wel...

A series of N-substituted phthalimide derivatives were synthesized based on a pharmacophore study of paecilocin A (a natural PPAR-γ agonist) and synthetic leads. The introduction of hydrophilic and hydrophobic groups to the phthalimide skeleton yielded compounds 3-14. Compound 7 showed significant PPAR-γ activation in a luciferase assay using rat liver Ac2F cells. Docking simulations showed tha...

The cleavage stimulation factor (CstF) is essential for the first step of poly(A) tail formation at the 3' ends of mRNAs. This heterotrimeric complex is built around the 77-kDa protein bridging both CstF-64 and CstF-50 subunits. We have solved the crystal structure of the 77-kDa protein from Encephalitozoon cuniculi at a resolution of 2 A. The structure folds around 11 Half-a-TPR repeats defini...

Density functional theory calculations are used to investigate the electronic structure of pyridine-based self-assembled monolayers (SAMs) on an Au(111) surface. We find that, when using pyridine docking groups, the bonding-induced charge rearrangements are frequently found to extend well onto the molecular backbone. This is in contrast to previous observations for the chemisorption of other SA...

Introduction Maintaining consumers trust is essential to ensure the future of the dairy industry. Production of high quality milk from healthy, well cared for animals is the goal of most dairy farmers. However, as fewer and fewer consumers are familiar with dairy farming, they have become more skeptical about the ability of farmers to properly care for farm animals. Public attention about the w...