نتایج جستجو برای: tableting
تعداد نتایج: 232 فیلتر نتایج به سال:
The deformation behavior of particles under pressure dominates the mechanical properties of solid dosage forms. In this study, the in situ 3D deformation of two polymorphs (I and II) of clopidogrel bisulfate (CLP) was determined to illustrate pressure distribution profiles within the tablet by the deformation of the crystalline particles for the first time. Synchrotron radiation X-ray computed ...
δ-mannitol is a metastable polymorph of mannitol, known for its superior tableting properties. However, there no easy, reproducible and scalable production method δ-mannitol. It was evaluated whether could be formed via co-spray drying with an API exhibiting tabletability issues, to improve the in one-step process prior compaction. Aqueous suspensions paracetamol β-mannitol were dried. Raman sp...
Abstract: Background: Cinacalcet Hydrochloride (CINH) is a BCS class IV drug. It mainly used for the treatment of chronic renal disease and parathyroid cancer. exhibits poor oral bioavailability less than 25%. The main objective to improve stability CINH by formulating lyophilized Nanostructure Lipid Carrier (NLC) into tablet dosage form. Materials Methods: In this research, Glycerylmonostearat...
Lubricants are indispensable pharmaceutical ingredients for preventing tableting failure due to powder adhesion the die wall. The impact of lubricants was evaluated with use Binding Identification Net Detriment (BIND) surface replication method. Raloxifene hydrochloride (RH) selected as a model chemical high adhesion, and four commercially available tablet – stearic acid, sodium stearyl fumarat...
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