A rat model of cerebral hemorrhage using stereotaxic injection of blood into the right basal ganglia was developed to investigate the influence of iron metabolism on the appearance of cerebral hemorrhage on MR images. Images of in vitro fixed brain sections stained specifically for different iron-storage substances, ferritin and hemosiderin, created by digitization of the pathology sections usi...

Quantitative nuclear magnetic resonance imaging (MRI) has been considered a promising non-invasive tool for monitoring therapeutic essays in small size mouse models of muscular dystrophies. Here, we combined MRI (anatomical images and transverse relaxation time constant-T2-measurements) to texture analyses in the study of four mouse strains covering a wide range of dystrophic phenotypes. Two st...

Introduction The articular cartilage in the knee joint provides load-bearing function along with adjacent meniscus and anterior/posterior cruciate ligaments, and injury of the meniscus, cruciate ligaments and articular cartilage may result in failure in responding to normal load-bearing. Previous clinical studies showed that 80% or more patients with injury of anterior cruciate ligaments result...

BACKGROUND The assessment of myocardial iron using T2* cardiovascular magnetic resonance (CMR) has been validated and calibrated, and is in clinical use. However, there is very limited data assessing the relaxation parameters T1 and T2 for measurement of human myocardial iron. METHODS Twelve hearts were examined from transfusion-dependent patients: 11 with end-stage heart failure, either foll...

OBJECTIVE Physiological magnetic resonance imaging (MRI) under loading or knee malalignment conditions has not been thoroughly investigated. We assessed the influence of static loading and knee alignment on T2 (transverse relaxation time) mapping of the knee femoral cartilage of porcine knee joints using a non-metallic pressure device. METHODS Ten porcine knee joints were harvested en bloc wi...

BACKGROUND Plantar pressure reduction is mandatory for diabetic foot ulcer healing. Our aim was to evaluate the impact of a new walking strategy learned by biofeedback on plantar pressure distribution under both feet in patients with diabetic peripheral neuropathy. METHODS Terminally augmented biofeedback has been used for foot off-loading training in 21 patients with diabetic peripheral sens...

INTRODUCTION The meniscus plays an important role in the biomechanical knee function. Previous experimental and clinical studies showed that menicectomy results in significant increase of local load transmission and leads to degeneration of the articular cartilage in the knee joint 1-3) . However, there has been no methods which allows three-dimensional (3D) assessment of load distribution in t...

background: iron-mediated cardiomyopathy is the main complication of thalassemia major (tm) patients. therefore, there is an important clinical need in the early diagnosis and risk stratification of patients. the aim of this study was to evaluate the efficacy of tissue doppler imaging (tdi) to study cardiac iron overload in patients with tm using t2* magnetic resonance (mr) as the gold-standard...