نتایج جستجو برای: t helper 1 th1

تعداد نتایج: 3215911  

Journal: :Experimental gerontology 2008
Peter Uciechowski Laura Kahmann Birgit Plümäkers Marco Malavolta Eugenio Mocchegiani George Dedoussis Georges Herbein Jolanta Jajte Tamas Fulop Lothar Rink

Elderly subjects suffer from increased levels of activated T cells and a TH1/TH2 imbalance. Zinc deficiency of the aged is correlated with decreased cell-mediated immune responses. The association of age and zinc adjustment with the amounts of TH1 (CCR5+) and TH2 (CCR4+) cell populations in healthy aged old donors enrolled in the European ZINCAGE project was examined. Old and nonagenarian indiv...

Journal: :Cardiovascular research 2003
Rima Elhage Jacek Jawien Mats Rudling Hans-Gustaf Ljunggren Kiyoshi Takeda Shizuo Akira Francis Bayard Göran K Hansson

OBJECTIVE Atherosclerosis is an inflammatory disease in which T helper 1 (Th1) immunity has been proposed to play an important role. Nai;ve CD4+ T cells differentiate into interferon-gamma (IFN-gamma) producing Th1 effector cells when stimulated by interleukin-18 (IL-18) and IL-12. We wanted to directly test whether the Th1 pathway is proatherogenic. METHODS We bred IL-18(-/-) mice with apoli...

Contact hypersensitivity (CHS) mouse model induced by 2, 4-dinitrofluorobenzene (DNFB) is thought to be a T helper 1 (Th1)-dominant response and used for investigating anti-inflammatory and immunosuppressive agents. However, it is hardly used for screening large-scale drugs because of the large number of animals and complex mechanisms involved in-vivo. In this study, we focused on whether T lym...

2015
Sun Young Yoon Ho Bum Kang Young-Eun Ko Su-Hyun Shin Young-Jun Kim Ki-Young Sohn Yong-Hae Han Saeho Chong Jae Wha Kim

Controlling balance between T-helper type 1 (Th1) and T-helper type 2 (Th2) plays a pivotal role in maintaining the biological rhythm of Th1/Th2 and circumventing diseases caused by Th1/Th2 imbalance. Interleukin 4 (IL-4) is a Th2-type cytokine and often associated with hypersensitivity-related diseases such as atopic dermatitis and allergies when overexpressed. In this study, we have tried to ...

Journal: :The Journal of Experimental Medicine 2000
Manfred Kopf Anthony J. Coyle Nicole Schmitz Marijke Barner Annette Oxenius Awen Gallimore Jose-Carlos Gutierrez-Ramos Martin F. Bachmann

It has been shown that certain pathogens can trigger efficient T cell responses in the absence of CD28, a key costimulatory receptor expressed on resting T cells. Inducible costimulator protein (ICOS) is an inducible costimulator structurally and functionally related to CD28. Here, we show that in the absence of CD28 both T helper cell type 1 (Th1) and Th2 responses were impaired but not abroga...

Journal: :Journal of Immunology 2023

Abstract Arginase 1 (ARG1), the enzyme catalyzing conversion of arginine to ornithine and urea, is a hallmark IL-10 producing immunosuppressive M2 macrophages, however ARG1 activity in T cells disputed. Here we demonstrate that Arg1, but not Arg2, expression induction key feature lung CD4 during mouse vivo influenza infection. Ablation cell-intrinsic Arg1 unexpectedly accelerated both virus-spe...

Journal: :Science 2002
Maria Yazdanbakhsh Peter G Kremsner Ronald van Ree

The increase of allergic diseases in the industrialized world has often been explained by a decline in infections during childhood. The immunological explanation has been put into the context of the functional T cell subsets known as T helper 1 (TH1) and T helper 2 (TH2) that display polarized cytokine profiles. It has been argued that bacterial and viral infections during early life direct the...

Journal: :Blood 2005
Graham M Lord Ravi M Rao Hyeryun Choe Brandon M Sullivan Andrew H Lichtman F William Luscinskas Laurie H Glimcher

Inflammatory responses are controlled by T helper 1 (Th1) lymphocytes. An important function of this polarity is the ability of T cells to traffick appropriately in vivo. This differential trafficking is dependent upon the binding of P-selectin glycoprotein ligand-1 to P- and E-selectin on inflamed endothelium as well as the expression of specific chemokine receptors. Here we show that in the a...

Journal: :Current Biology 2002
Douglas S Robinson Clare M Lloyd

The transcription factors T-bet and GATA3 are important reciprocal determinants of Th1 and Th2 T helper cell differentiation. Recent evidence suggests that these factors may affect airway immunopathology in asthma.

Journal: :Blood 2001
Y Lu S Sakamaki H Kuroda T Kusakabe Y Konuma T Akiyama A Fujimi N Takemoto K Nishiie T Matsunaga Y Hirayama J Kato S Kon K Kogawa Y Niitsu

Acute graft-versus-host diseases (GVHD) is a major cause of morbidity and mortality in patients undergoing allogeneic bone marrow transplantation (BMT). T helper 1 (Th1)-type cytokines such as interferon-gamma or tumor necrosis factor-alpha have been implicated in the pathogenesis of acute GVHD. TAK-603 is a new quinoline derivative, which is now in clinical trials for use as a disease-modifyin...

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