In order to study the genetic control of semen quality parameters, we derived a set of recombinant inbred (RI) mice from crosses between two inbred strains, KE and CBA/Kw, which differ significantly in gamete quality and fertility parameters. In this work, we used male mice from the two parental strains and from ten RI strains to map genes controlling quantitative traits such as sperm mitochond...

Cbl-Crkl and Crkl-C3G interactions have been implicated in T cell and B cell receptor signaling and in the regulation of the small GTPase, Rap1. Recent evidence suggests that Rap1 plays a prominent role in the regulation of immunoreceptor tyrosine-based activation motif (ITAM) signaling. To gain insight into the role of Crkl in myeloid ITAM signaling, we investigated Cbl-Crkl and Crkl-C3G inter...

In mast cells, cross-linking the high-affinity IgE receptor (Fc(epsilon)RI) initiates the Lyn-mediated phosphorylation of receptor ITAMs, forming phospho-ITAM binding sites for Syk. Previous immunogold labeling of membrane sheets showed that resting Fc(epsilon)RI colocalize loosely with Lyn, whereas cross-linked Fc(epsilon)RI redistribute into specialized domains (osmiophilic patches) that excl...

Neuroadapted Sindbis virus (NSV) infection of mice causes hindlimb paralysis and 100% mortality in the C57BL/6 mouse strain, while adults of the BALB/cBy mouse strain are resistant to fatal encephalomyelitis. Levels of viral RNA are higher in the brains of infected C57BL/6 mice than in BALB/cBy mice (D. C. Thach et al., J. Virol. 74:6156-6161, 2000). These phenotypic differences between the two...

c o lle c ti o n o f m e a n in g fu l e v id e n c e . D ra w in g h e a v ily f ro m t h e v a lu e -b a s e d r u b ri c s d e v e lo p e d b y t h e A s s o c ia ti o n o f A m e ri c a n C o lle g e s a n d U n iv e rs it ie s (A A C & U ), a H ig h e r L e a rn in g C o m m is s io n w o rk s h o p i n F e b ru a ry 2 0 1 1 , a n d o th e r in s ti tu ti o n s , th e s e d e s c ri p ti v...

potassium bromide (kbr), an old antiepileptic agent, is illegally used in pharmaceutical or food industries to improve the product appearance. kbr has been proven to influence several pathways which are important in memory formation. therefore, the present study aimed to evaluate the effect of kbr on spatial working memory using object recognition task (ort). rats received a single dose of kbr ...

general and specific combining ability of some rice lines and cultivars with irri sources were determined using the line × tester procedure (5 pure lines were crossed with 4 local cultivars as tester). parents and their progenies were planted in a randomized complete block design with three replications in the research field of iran rice research institute. traits such as yield and its componen...

This research suggests that a Darwinian evolution of entrepreneurial spirit played a significant role in the process of economic development and the dynamics of inequality within and across societies. The study argues that entrepreneurial spirit evolved non-monotonically in the course of human history. In early stages of development, risk-tolerant, growth promoting traits generated an evolution...