OBJECTIVE Several studies reported the local tissue reaction caused by mineral aggregate-based cements. However, few studies have investigated the systemic effects promoted by these cements on liver and kidney when directly applied to connective tissue. The purpose of this in vivo study was to investigate the systemic effect of mineral aggregate-based cements on the livers and kidneys of rats. ...

Various skin and systemic symptoms may develop as a complication of treatment with different medications and medicinal substances. One of them is a relatively rare drug reaction with eosinophilia and systemic symptoms, referred to as DRESS syndrome. The morphology of skin lesions and the patient's general health can differ; the management involves withdrawal of drugs suspected of triggering DRE...

Systemic Diseases of Connective Tissue with Autoimmunization. Rheumatism. Rheumatoid Arthritis. Systemic Lupus Erythematosus. Scleroderma. Dermatomyositis. Bechterew’s (Strumpell’s) disease Systemic Diseases of Connective Tissue or Rheumatic diseases are a group of chronic diseases characterized by systemic lesion of connective tissue and blood vessels. In their aetiology a significant role i...

BACKGROUND Despite its clinical effectiveness, allergen immunotherapy (AIT) remains controversial because serious systemic reactions can occur during its administration. Most of the studies on the safety of AIT are retrospective and use different methods, which frequently depart from daily clinical practice. OBJECTIVE The aim of this study was to determine risk factors for adverse reactions, ...