Allergic pathology of skin is one the most pressing problems modern pediatry. The common allergic dermatoses: simple and contact dermatitis, atopic various forms eczema, acute chronic urticaria, Quincke's edema, toxicodermias, multiforme exudative erythema (Stevens-Johnson syndrome), epidermal necrolysis (Lyell's syndrome). Many aspects systemic treatment dermatoses in children are complex cont...

Polymyalgia rheumatica (PMR) is an age-related chronic inflammatory disease with rheumatic features at the fore. In addition to high-grade systemic inflammation, it characterized by typical “polymyalgic” musculoskeletal symptoms, including diffuse and severe pain prolonged morning stiffness of shoulder girdle, pelvic neck. PMR a member so-called giant cell arteritis complex; however, in spite m...

Increased mortality has been observed in patients who develop acute kidney injury (AKI) the setting of coronavirus disease 2019 (COVID-19), which led to approval extracorporeal support by FDA. We analyzed existing literature compare efficacy and therapeutic benefits various modalities for oXiris membranes CytoSorb cartridge high-flow continuous replacement therapy (HFCKRT). AKI due COVID-19 is ...

Sepsis is a common clinical syndrome characterized by infection accompanied by systemic inflammation. The systemic inflammation (systemic inflammatory response syndrome – SIRS), which may be also related to non-infectious causes (Fig. 1), manifests itself as changes in temperature (>38oC or <36oC), tachycardia (>90 per minute), tachypnea (>20 per minute), or changes in white blood cell count in...

This paper will review the involvement of disseminated intravascular coagulation-induced microvascular thrombosis in the pathogenesis of multiple organ dysfunction syndrome and the interaction between disseminated intravascular coagulation and systemic inflammatory response syndrome in critically ill patients. The published literature on clinical and experimental studies are the data sources of...

PURPOSE Host response to polytrauma occasionally has unpredictable outcomes. Immune response is a major factor influencing patient's outcome. This study evaluated the interaction of two main cytokines in immune response after major trauma, specifically interleukin-6 (IL-6) and interleukin-10 (IL-10). Plasma level of these cytokines is determined by mRNA expression of these cytokines genes which...

INTRODUCTION Acid sphingomyelinase is involved in lipid signalling pathways and regulation of apoptosis by the generation of ceramide and plays an important role during the host response to infectious stimuli. It thus has the potential to be used as a novel diagnostic marker in the management of critically ill patients. The objective of our study was to evaluate acid sphingomyelinase serum acti...

Immunoglobulin G4-related disease (IgG4-RD) is a systemic disease characterized by lymphoplasmacytic inflammation, fibrosis, and elevated levels of IgG4 in tissues and eventually in the blood. IgG4-RD is a recently described disease and encompasses classic entities such as Riedel’s thyroiditis, Mikulicz syndrome, and Küttner’s tumor. It is a rare disease that affects middle-aged men, especially...

1. Departamento de Medicina Clínica, Universidade Federal do Ceará, Fortaleza (CE) Brasil. Numerous pharmacological therapies for acute respiratory distress syndrome (ARDS) have failed to demonstrate a benefit in multicenter clinical trials.(1) Given that dysregulated inflammation is a prominent feature of ARDS, systemic corticosteroids are thought to represent a potentially beneficial therapy.(2)

Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute and severe decompensation of chronic disease (CLD) correlated with multiple organ failure, poor prognosis, increased mortality. In 40–50% ACLF cases, the trigger not recognized; for many these patients, bacterial translocation associated systemic inflammation thought to be determining factor; in other 50% sepsis, alcohol...