A number of studies have shown that the extracellular pH (pHe) in cancers is typically lower than that in normal tissue and that an acidic pHe promotes invasive tumor growth in primary and metastatic cancers. Here, we investigate the hypothesis that increased systemic concentrations of pH buffers reduce intratumoral and peritumoral acidosis and, as a result, inhibit malignant growth. Computer s...

Multiple primary cancers are the occurrence of more than two cancers of different origin in an individual. Penile cancer is a rare disease, and finding it combined with other cancers is even rarer. A 64-year-old man with a painful penile mass was referred to us from a primary urological clinic. We performed a biopsy of the penile mass and the histology revealed a well-differentiated squamous ce...

BACKGROUND Sjögren's syndrome is a chronic, systemic disorder of an autoimmune nature, and its primary etiopathogenetic events are not known. Previous studies have found elevated incidence of malignancies in patients with primary Sjögren's syndrome. However, there are few reports regarding the association of Sjögren's syndrome with skin cancers, especially with multiple skin cancers developed w...

BACKGROUND Lynch syndrome (LS) is an inherited colorectal cancer (CRC) syndrome accounting for about 3-5% of all cases and involves significantly higher risk of subsequent malignancies, colonic as well as extra-colonic. Increased risk of malignancies, especially lymphoid malignancies, have been described in patients with autoimmune diseases like rheumatoid arthritis (RA), systemic lupus erythem...

Cancers of the colon and rectum will affect 1 in 17 North Americans during their lifetime. The progress witnessed in the treatment of these cancers in recent years has been remarkable. Improvements have been realized in surgical technique, radiation therapy, and systemic therapies, particularly with the addition of oxaliplatin and irinotecan to the previously limited armamentarium of fluorourac...

abo blood type antigens are polymorphic, inherited structures presented on the surface of red blood cells. although abo blood group antigens is the most important antigens in transfusion medicine, its main role is not clearly clarified. correlation between abo blood group and susceptibility to certain infectious and non-infectious diseases is a controversial issue. since, lack of blood type ant...

objective: in this study, we aimed at evaluation of the efficacy of hypericum perforatum and flaxseed on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women materials and methods: we searched medline, scopus, and the cochrane central register of controlled trials (rct) to explore trials that assessed the effectiveness of h. perforatum and flaxseed on hot flash, vaginal...

The management of patients with recurrent head and neck cancers remains a challenging clinical dilemma. Concerns over toxicity with re-irradiation have limited its use in the clinical setting. Stereotactic Body Radiation Therapy (SBRT) has emerged as a highly conformal and precise type of radiotherapy and has the advantage of sparing normal tissue. Although SBRT is an attractive treatment modal...

Abstract Agonistic antibodies targeting CD137 have been clinically unsuccessful due to systemic toxicity. Because conferring tumor selectivity through tumor-associated antigen limits its clinical use cancers that highly express such antigens, we exploited extracellular adenosine triphosphate (exATP), which is a hallmark of the microenvironment and elevated in solid tumors, as broadly tumor-sele...

paragangliomas are extra-adrenal counterparts of pheochromocytomas and are found at various anatomical sites such as the retroperitoneum, mediastinum, jugular foramen and carotid bifurcation, the latter two fonns being coined as chemodectomas. the vertebral column, especially the llullbar zone, is one of the rarest sites to be involved by paragangliomas. these lesions may have secretory functio...