www.ondrugdelivery.com 27 In this article, Mahesh Chaubal, PhD, Senior Director, Drug Development, R&D Medical Products, Baxter Healthcare Corporation, provides a glimpse of some of the challenges faced during the development of viscous formulations of biopharmaceutical products for injection, from a formulator’s perspective, especially when the finished product is filled in a prefilled syringe...

BACKGROUND Coverage is used as one indicator of needle and syringe program (NSP) effectiveness. At the individual level, coverage is typically defined as an estimate of the proportion of a person who injects drugs' (PWID) injecting episodes that utilise a sterile syringe. In this paper, we explore levels of individual syringe coverage and its changes over time. METHODS Data were extracted fro...

Immunocontraceptive vaccines have shown some promise for fertility control of white-tailed deer (Odocoileus virginianus) in urban and suburban habitats where traditional methods of population control may not be applicable. Currently, the only contraceptive vaccine approved by the U.S. Environmental Protection Agency for use in white-tailed deer is GonaConTM Immunocontraceptive Vaccine, but it i...

OBJECTIVE The purpose of this prospective, randomized, blinded study was to compare the pain of injection and post-injection pain of the AMSA injection using the computer-assisted Wand Plus injection system versus a conventional syringe. STUDY DESIGN Using a crossover design, 40 subjects randomly received 2 blinded AMSA injections using the Wand Plus system and a conventional syringe, at 2 se...

Name Type Company Catalog Number Comments Dithizone reagent Dissolve 5mg Dithizone in 5 ml of DMSO in a 50 ml conical tube. Add 45 ml of normal saline and mix gently. Filter with a 60 cc syringe and a 0.22 "m syringe filter into a new 50 ml tube. Store at 4 OC, until use. Add 1 ml to each 35 mm counting Grid-plate, when needed. PBS Buffer HBSS Buffer Isolation soln. Buffer HBSS containing 10 mM...

Copyright © 2009 ONdrugDelivery Publishing Ltd 22 Suppliers of pharmaceutical packaging components and delivery devices have been working closely with the industry in an effort to provide solutions for mitigating the risk associated with extractables and leachables. This effort includes managing both the technical and regulatory aspects of the subject. The following example illustrates the chal...

We designed a simple model to illustrate posterior nasal packing to inexperienced trainees in a classroom environment. The plunger and the smaller end of a 20ml syringe, which is cut off, are discarded. The hollow syringe represents the nasal cavity. A Foley catheter is inserted from one end until it exits at the other end, representing the catheter’s tip seen in the oropharynx. While pulling t...

SUMMARY Removal of an intact, inflated tissue expander can result in uncontrolled spillage of expander contents on the drapes, surgeons, staff, or patient. The technique described has been used for the past 4 years to eliminate these spillage concerns. It is simple and inexpensive using common disposable supplies found in any operating room. An irrigating syringe is modified by cutting away its...

Dispersive liquid liquid microextraction (DLLME) combined with gas chromatography–mass spectrometry (GC–MS) was used for the extraction and determination of 13 polycyclic aromatic hydrocarbons (PAHs) in mineral water samples. In this procedure, the suitable combination of extraction solvent (500 µL chloroform) and disperser solvent (1000 µL acetone) were quickly injected into the water sample (...

THE ~-'v~OST COM~ON too1 in medical research is the glass syringe. It is often employed for the sampling of various gases, vapours, and their mixtures, During our experiments regarding reproducibility of anaesthetic vapour-gas mixtures, we found that the results depended considerably upon the time the mixture remained in the syringe before analysis. After considering and eliminating other possi...