PURPOSE The purpose of this study was to describe the arthroscopic clinical findings and treatment in patients with pathologic hypertrophy of the synovium in the anteromedial joint compartment in conjunction with anteromedial knee pain. TYPE OF STUDY Case series. METHODS A group of 21 patients, ranging in age from 11 to 68 years (mean, 29 years) with pathologic hypertrophic changes of the s...

Immune complexes have been found in the synovial fluid (Rawson, Abelson, and Hollander, 1965) and synovium (Kinsella, Baum, and Ziff, 1970) of patients with rheumatoid arthritis. They have also been discovered in the blood in cases of the same disease (Kunkel, Miiller-Eberhard, Fudenberg, and Tomasi, 1961) and their presence has lead to speculation on their role in the aetiology of rheumatoid d...

The application of boron neutron capture therapy to rheumatoid arthritis requires the selective delivery of the boron-10 isotope to the synovitic tissue. The use of liposomes as a boron delivery method has been explored through the measurement of the time course biodistribution of boron in rats with collagen-induced arthritis (CIA). Small unilamellar vesicles were composed of a 1:1 mixture of d...

BACKGROUND Synovial osteochondromatosis is a benign metaplastic proliferative disorder of the synovium characterised by the formation of multiple cartilaginous nodules in the synovium, many of which detach and become loose bodies. The disease is characteristically monoarticular, most commonly involving the knee. A site in the elbow was first reported in 1918 by Henderson, but any joint may be i...

BACKGROUND Volumes of inflamed synovial membrane determined by magnetic resonance imaging (MRI) are closely related to histopathological synovitis and may predict erosive progression in rheumatoid arthritis (RA). However, after IV injection, leakage of MRI contrast from the synovium gradually compromises the differentiation of synovium from joint fluid. OBJECTIVE To determine the time period ...

OBJECTIVE We previously described a messenger RNA variant of ADAMTS4 (ADAMTS4_v1) in human synovial cell cocultures obtained from patients with osteoarthritis (OA). This RNA message has been found only in OA synovium and, if translated, would result in a protein identical to ADAMTS-4, except that the C-terminal spacer domain would be different. The purpose of this study was to determine whether...

OBJECTIVE Treatment options for rheumatoid arthritis range from symptomatic approaches to modern molecular interventions such as inhibition of inflammatory mediators. Inhibition of inflammation by platelet-rich plasma (PRP) has been proposed as a treatment for tendinitis and osteoarthritis. The present study was undertaken to investigate the effect of PRP on antigen-induced arthritis (AIA) of t...