BACKGROUND Novel immune checkpoint inhibitors have been often utilized for different types of malignancies as salvage therapy with varying success. One obstacle to immune checkpoint inhibitor use is the higher incidence of immune-mediated side effects that can prompt discontinuation of therapy. Remitting seronegative symmetrical synovitis with pitting edema has been described with immune checkp...

Considering the relation between synovial inflammation and global disease activity in rheumatoid arthritis (RA) and the distinct but heterogeneous histology of spondyloarthropathy (SpA) synovitis, the present study analyzed whether histopathological features of synovium reflect specific phenotypes and/or global disease activity in SpA. Synovial biopsies obtained from 99 SpA and 86 RA patients w...

The subject of syphilitic synovitis in children has not received the attention it deserves from medical and surgical writers, and the importance of the condition entitles it to a much wider recognition than has hitherto been accorded to it. It is generally regarded as an affection of great rarity, and in the textbooks on diseases of children it is either completely ignored, or the subject is su...

Three-year clinical outcome following baseline magnetic resonance imaging in anti-citrullinated protein antibody-positive arthralgia patients: an exploratory study ABSTRACT Objective: To investigate whether magnetic resonance imaging (MRI) can visualize subclinical synovitis in arthralgia patients with positive anti-citrullinated protein antibodies (ACPA), and to determine the relationship betw...

Objective: Our aim was to establish the existence of intercellular communication through gap junctions (ICGJ) in synovial tissues and to show that gap junction communications in synovial tissue plays a role in the pathogenesis of synovitis in patients with rheumatoid arthritis (RA). Material and methods: Synovial tissues were obtained from patients with RA and osteoarthritis (OA) at the time of...

BACKGROUND Synovial inflammation (as defined by hypertrophy and effusion) is common in osteoarthritis (OA) and may be important in both pain and structural progression. OBJECTIVE To determine if decision rules can be devised from clinical findings and ultrasonography (US) to allow recognition of synovial inflammation in patients with painful knee OA. METHODS A EULAR-ESCISIT cross sectional,...

AIMS To investigate the histopathological features of the synovial lining of the knee following implantation of an artificial cruciate ligament. METHODS Eighty two patients underwent anterior cruciate ligament reconstruction for chronic, symptomatic instability of the knee. The cruciate ligament was reconstructed with a scaffold type prosthetic ligament. All patients underwent arthroscopy at ...

OBJECTIVE Magnetic resonance imaging (MRI) is increasingly used to measure articular inflammation and damage in patients with psoriatic arthritis (PsA). We evaluated the reliability of a new OMERACT PsA MRI scoring system, PsAMRIS, in PsA fingers. METHODS In 2 separate studies, MRI scans were obtained from patients with clinical evidence of synovitis or dactylitis of the fingers. For the firs...

INTRODUCTION Synovial inflammation and joint destruction in rheumatoid arthritis (RA) may progress despite clinical remission. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is increasingly used to detect synovial inflammation in RA. Although small joints such as metacarpophalangeal (MCP) joints are mainly affected by RA, MRI findings have never been directly compared to histolo...

The incidence of rice bodies (RB) in synovial effusions has been studied in 36 patients with rheumatoid arthritis (RA) and in 12 patients with seronegative inflammatory arthritis (7 cases of Still's disease, 3 of psoriatic arthritis, and 2 of ankylosing spondylitis). In the RA group 50 joints were aspirated before and after saline lavage with a specially designed wide-bore needle. RB were found...