AIM/BACKGROUND Medicinal plants have ability to resist microorganisms by synthesizing secondary metabolites such as phenols. Rosmarinic acid (RA) is a phenylpropanoid widely distributed in plants and well known as therapeutic and cosmetic agent. Methicillin-resistant Staphylococcus aureus (MRSA) which is resistant to all kinds of β-lactams, threatens even most potent antibiotics. To improve the...

Ceramide (CE)-based combination therapy (CE combination) as a novel therapeutic strategy has attracted great attention in the field of anti-cancer therapy. The principal purposes of this study were to investigate the synergistic effect of CE in combination with docetaxel (DTX) (CE + DTX) and to explore the synergy mechanisms of CE + DTX. The 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium ...

background: radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. however, due to the development of radio-resistance, tumor recurrence and metastasis often occur following radiation therapy. in recent years, combination of radiotherapy and gene therapy has been suggested to overcome this problem. the aim of the current study was to e...

the aim of the present study was to investigate the influence and the mechanisms of cineoleand terpineol on the in-vitro transdermal delivery of huperzine a from microemulsions, andtheir potential synergistic effect on the permeation enhancement. the transdermal deliveryof huperzine a from microemulsions with different concentrations of cineole and terpineolthrough the rat abdominal skin was de...

For any given taxonomic divergence event, one may find in the literature a wide range of time estimates. Many factors contribute to the variation in molecular date estimates for the same evolutionary event. High on the list is the choice of calibration points for converting genetic distances into evolutionary rates and, subsequently, into dates of divergence. In this study, we investigate one c...

Individuals with Parkinson's disease and the aged have a high prevalence of falls. Since an increase in the number of falls is associated with physical and psychological harm, it is prudent that biomechanical metrics be established that will accurately assess an individual's walking balance. In this investigation, we initially used a simple bipedal walking computer model to theoretically establ...