نتایج جستجو برای: synaptosome

تعداد نتایج: 328  

2015
Binhui Ren Zoulikha Azzegagh Ana M. Jaramillo Yunxiang Zhu Ana Pardo-Saganta Rustam Bagirzadeh Jose R. Flores Wei Han Yong-jun Tang Jing Tu Denise M. Alanis Christopher M. Evans Michele Guindani Paul A. Roche Jayaraj Rajagopal Jichao Chen C. William Davis Michael J. Tuvim Burton F. Dickey

Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23 (23-kDa paralogue of synaptosome-associated protein of 25 kDa), selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regu...

2013
Yan Sai Junfeng Chen Feng Ye Yuanpeng Zhao Zhongmin Zou Jia Cao Zhaojun Dong

Rotenone is an inhibitor of mitochondrial complex I that produces a model of Parkinson's disease (PD), in which neurons undergo dopamine release dysfunction and other features. In neurons, exocytosis is one of the processes associated with dopamine release and is dependent on Ca(2+) dynamic changes of the cell. In the present study, we have investigated the exocytosis of dopamine and the involv...

Journal: :The Journal of Cell Biology 1985
C Hyman K H Pfenninger

The focus of this study is a quantitative biochemical analysis of the calcium-dependent interactions of calmodulin with a nerve growth cone preparation from fetal rat brain (Pfenninger, K. H., L. Ellis, M. P. Johnson, L. B. Freidman, and S. Somlo, 1983, Cell 35:573-584). The presence of calmodulin as an integral component of this preparation is demonstrated, and quantitative binding studies are...

Journal: :Neurochemistry international 2000
C B Pocernich M La Fontaine D A Butterfield

Glutathione deficiency has been associated with a number of neurodegenerative diseases including Lou Gehrig's disease, Parkinson's disease, and HIV. A crucial role for glutathione is as a free radical scavenger. Alzheimer's disease (AD) brain is characterized by oxidative stress, manifested by protein oxidation, lipid oxidation, oxidized glutathione, and decreased activity of glutathione S-tran...

2015
Rachel A K Atkinson Carmen M. Fernandez-Martos Julie D. Atkin James C. Vickers Anna E. King

INTRODUCTION A majority of familial frontotemporal lobar dementia and amyotrophic lateral sclerosis cases are associated with a large repeat expansion in a non-coding region of the C9ORF72 gene. Currently, little is known about the normal function and the expression pattern of the C9ORF72 protein. The aims of this study were to characterize the expression pattern and cellular localization of th...

Journal: :Neuroscience letters 2010
Romain-Daniel Gosselin Damien Bebber Isabelle Decosterd

Neuropathic pain is a major health issue and is frequently accompanied by allodynia (painful sensations in response to normally non-painful stimulations), and unpleasant paresthesia/dysesthesia, pointing to alterations in sensory pathways normally dedicated to the processing of non-nociceptive information. Interestingly, mounting evidence indicate that central glial cells are key players in all...

Journal: :Endocrinology 1997
B Höhne-Zell A Galler W Schepp M Gratzl C Prinz

Gastric enterochromaffin-like (ECL) cells release histamine upon stimulation with gastrin in a calcium-dependent manner. The intracellular mechanisms and proteins mediating exocytosis of histamine-containing vesicles in ECL cells have not been determined yet. We used immunocytochemistry to show the localization of SNAP-25 (synaptosome-associated protein of 25 kDa) and synaptobrevin VAMP (vesicl...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Sonal Thakar Liqing Wang Ting Yu Mao Ye Keisuke Onishi John Scott Jiaxuan Qi Catarina Fernandes Xuemei Han John R Yates Darwin K Berg Yimin Zou

The signaling mechanisms that choreograph the assembly of the highly asymmetric pre- and postsynaptic structures are still poorly defined. Using synaptosome fractionation, immunostaining, and coimmunoprecipitation, we found that Celsr3 and Vangl2, core components of the planar cell polarity (PCP) pathway, are localized at developing glutamatergic synapses and interact with key synaptic proteins...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Vedrana Montana Yingchun Ni Vice Sunjara Xue Hua Vladimir Parpura

Astrocytes exhibit excitability based on variations of their intracellular Ca2+ concentrations, which leads to glutamate release, that in turn can signal to adjacent neurons. This glutamate-mediated astrocyte-neuron signaling occurs at physiological intracellular Ca2+ levels in astrocytes and includes modulation of synaptic transmission. The mechanism underlying Ca2+-dependent glutamate release...

Journal: :Molecular biology of the cell 2005
Constantin Rüder Tatiana Reimer Ignacio Delgado-Martinez Ricardo Hermosilla Arne Engelsberg Ralf Nehring Bernd Dörken Armin Rehm

Regulated exocytosis is subject to several modulatory steps that include phosphorylation events and transient protein-protein interactions. The estrogen receptor-binding fragment-associated gene9 (EBAG9) gene product was recently identified as a modulator of tumor-associated O-linked glycan expression in nonneuronal cells; however, this molecule is expressed physiologically in essentially all m...

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