Die Visualisierung von inhibitorischen Synapsen erfordert auf Sondentypen und das jeweilige bildgebende Verfahren abgestimmte Protokolle beruht in der Regel genetischer Manipulation oder Verwendung Antikörpern, die bei Gewebefärbungen unter ihrer geringen Eindringtiefe leiden. Abgestimmt Gephyrin Protein, einem universellen Marker Synapse, haben wir eine kompakte, hochaffine hochselektive pepti...

Neurexins are presynaptic cell-adhesion molecules that bind to postsynaptic cell-adhesion molecules such as neuroligins and leucine-rich repeat transmembrane proteins (LRRTMs). When neuroligins or LRRTMs are expressed in a nonneuronal cell, cocultured neurons avidly form heterologous synapses onto that cell. Here we show that knockdown of all neurexins in cultured hippocampal mouse neurons did ...

function as retrograde signaling molecules that regulate developmental synapse elimination in the cerebellum. Our results suggest that Sema3A and Sema7A have opposite effects and are involved in different stages of synapse elimination (fig. S22). Because semaphorins and their receptors are expressed widely in the brain, it is highly likely that semaphorins play important roles in developmental ...

Action potential or Spikes: electrical pulses of an amplitude of about 100mV that travel along nerve fibers. Field potential an electrical signal recorded extracellularly which arises from the synchronized activity of many cells. Hippocampus one of the most studied area of the mammalian nervous system which is part of the limbic system and is involved in learning and memory. Neuron the main exc...