Our interest on engineering non-ribosomal synthetase responsible for SW-163 biosynthesis prompted us to determine the relative and absolute configuration of antitumor cyclic depsipeptide SW-163s. We first isolated and identified SW-163 homologs D, F and G as known compounds UK-63598, UK-65662 and UK-63052, respectively. Both enantiomers of the unusual constitutive amino acid, N-methylnorcoromic...

The Semantic Web (SW) service is a web application using Semantic Web techniques which usually involve cooperation between several intelligent agents. The design of SW systems requires precise modelling techniques to capture ontology domain properties and application functionalities. We believe that Z as a specification technique can contribute to the Semantic Web-based system development in ma...

We consider the propagation of a shock wave (SW) in the damped Toda lattice. The SW is a moving boundary between two semi-infinite lattice domains with different densities. A steadily moving SW may exist if the damping in the lattice is represented by an “inner” friction, which is a discrete analog of the second viscosity in hydrodynamics. The problem can be considered analytically in the conti...

This review addresses an often overlooked aspect of elasmobranch osmoregulation, i.e., control of body fluid volume. More specifically the review addresses the impact of changes in blood volume in elasmobranchs exposed to different environmental salinities. Measurement of blood volume in the European lesser-spotted dogfish, Scyliorhinus canicula, following acute and chronic exposure to 80% and ...

The SW Sex stars are a class of cataclysmic variables, originally identified because they shared a number of enigmatic properties – most notably, single-peaked emission lines instead of the double-peaked lines one would expect from their high-inclination accretion discs. We present high-time-resolution spectrophotometry of the eclipsing nova-like variables SW Sex and DW UMa, two of the founding...

Silkworm antitrypsin (sw-AT), which was thought to belong to serpin family, changed its behavior against denaturation after chymotryptic cleavage of a single peptide bond (Tyr-Val) two amino acids away from the reactive site for trypsin (Lys-Val). This chymotrypsin-modified sw-AT became resistant to denaturation by heat, sodium dodecyl sulfate, or guanidine hydrochloride, and this characteristi...

The Semantic Web (SW) was originally positioned as a combination of Knowledge Representation (KR) and the Web. However, most applications that use SW data today lean more towards the Information Retrieval spectrum. The reason for this is that traditional KR systems are designed to work with datasets that are small, curated, homogeneous, and application-specific. However, the SW is large-scale, ...

The electronic transport of zigzag-edged graphene nanoribbon (ZGNR) with local Stone-Wales (SW) defects is systematically investigated by first principles calculations. While both symmetric and asymmetric SW defects give rise to complete electron backscattering region, the well-defined parity of the wave functions in symmetric SW defects configuration is preserved. Its signs are changed for the...

Email: [email protected], Email:[email protected], Email: [email protected],Email:[email protected] * Department of Computer Science, COMSATS Institute of Information Technology M. A. Jinnah Campus, Defence Road off Raiwind Road, Lahore Pakistan. ABSTRACT: Software (SW) development is a very tough task which requires a skilled project leader for its success. If the ...

BACKGROUND Alzheimer's disease (AD) is considered to be a neurodegenerative disorder that is characterized by increased oxidative stress. Medicinal plants, with their antioxidant properties, have been used to cure several human diseases. The aim of the current study was to explore the protective and therapeutic effect of baicalein on AD-induced rats. MATERIALS AND METHODS Swiss Wistar rats we...