نتایج جستجو برای: sustained virologic response

تعداد نتایج: 1043902  

2015
Yuri Cho Eun Ju Cho Jeong-Hoon Lee Su Jong Yu Jung-Hwan Yoon Yoon Jun Kim

BACKGROUND/AIMS The previous standard treatment for chronic hepatitis C (CHC) patients, comprising a combination of pegylated interferon (IFN) and ribavirin, was associated with suboptimal efficacy and severe adverse reactions. A new era of direct-acting antivirals is now dawning in Korea. Early experience of applying sofosbuvir-based therapy to CHC patients in Korea is reported herein. METHO...

2014
John A. Howe Jianmin Long Stuart Black Robert Chase Patricia McMonagle Stephanie Curry Seth Thompson Mark J. DiNubile Anita Y. M. Howe

BACKGROUND We analyzed the impact of pretreatment variants conferring boceprevir-resistance on sustained virologic response (SVR) rates achieved with boceprevir plus peginterferon-α/ribavirin (P/R) for hepatitis C virus (HCV)-genotype-1 infection. METHODS NS3-protease-polymorphisms emerging coincident with virologic failure on boceprevir/P/R regimens were identified as resistance-associated v...

Journal: :American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013
J Levitsky K Doucette

Abbreviations: FCH, fibrosing cholestatic hepatitis; HAV, hepatitis A virus; HBIG, hepatitis B immunoglobulin; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HCV-R, HCV recurrence; HDV, hepatitis D virus; HEV, hepatitis E virus; HVPG, hepatic venous pressure gradient; IgM, immunoglobulin M; LADR, low accelerated dose regimen; LAM, lamivudine; IFNa , interferon al...

Journal: :Gastroenterology & hepatology 2012
Joseph S Galati

JSG The chance of clearing the virus and achieving a sustained virologic response (SVR) nearly doubled with the addition of these protease inhibitors. This improvement gave many people in the field of medicine a sense of renewal, as we finally have new agents to add to the interferon and ribavirin regimen that was the standard treatment for hepatitis C virus (HCV) infection for more than 10 years.

2014
Ho Kil Sook-Hyang Jeong Jin-Wook Kim Young Sang Byoun Bo Young Min Byung-Hyun Woo Youn Jae Lee Young Seok Kim

BACKGROUND/AIMS This study investigated the role of single nucleotide polymorphisms (SNPs) near the interleukin-28B (IL28B) gene with respect to clinical outcomes and the antiviral response in hepatitis C virus (HCV) infection to suggest the practical utility of IL28B genotyping in Korea. METHODS Two SNPs near IL28B, rs12979860 and rs8099917, were analyzed using an allelic discrimination assa...

Journal: :The New England journal of medicine 2014
Stefan Zeuzem Geoffrey M Dusheiko Riina Salupere Alessandra Mangia Robert Flisiak Robert H Hyland Ari Illeperuma Evguenia Svarovskaia Diana M Brainard William T Symonds G Mani Subramanian John G McHutchison Ola Weiland Hendrik W Reesink Peter Ferenci Christophe Hézode Rafael Esteban

BACKGROUND In clinical trials, treatment with a combination of the nucleotide polymerase inhibitor sofosbuvir and the antiviral drug ribavirin was associated with high response rates among patients with hepatitis C virus (HCV) genotype 2 infection, with lower response rates among patients with HCV genotype 3 infection. METHODS We conducted a study involving patients with HCV genotype 2 or 3 i...

2016
Catherine A. Koss Paul Natureeba Dorcas Nyafwono Albert Plenty Julia Mwesigwa Bridget Nzarubara Tamara D. Clark Theodore D. Ruel Jane Achan Edwin D. Charlebois Deborah Cohan Moses R. Kamya Diane V. Havlir Sera L. Young

Food insecurity is associated with poor virologic outcomes, but this has not been studied during pregnancy and breastfeeding. We assessed sustained viral suppression from 8 weeks on antiretroviral therapy to 48 weeks postpartum among 171 pregnant and breastfeeding Ugandan women; 74.9% experienced food insufficiency. In multivariable analysis, food insufficiency [adjusted odds ratio (aOR) 0.38, ...

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