Herein, we report a novel and solvent-free technique for the encapsulation of pharmaceuticals that allows achieving controllable release rates. This method utilizes the deposition of a plasma polymer coating of controlled chemistry and thickness on the outer surface of drug particles placed under continuous agitation.

In this study, Damar Batu (DB) − a novel biomaterial− is evaluated for its potential application in pharmaceutical coating. DB is a whitish to yellowish resin, characterized initially in terms of solubility, acid value, molecular weight (Mw), polydispersity index (Mw/Mn) and glass transition temperature (Tg). Neat plasticized films of DB are investigated for mechanical, water vapor transmission...

In this study, Damar Batu (DB) − a novel biomaterial− is evaluated for its potential application in pharmaceutical coating. DB is a whitish to yellowish resin, characterized initially in terms of solubility, acid value, molecular weight (Mw), polydispersity index (Mw/Mn) and glass transition temperature (Tg). Neat plasticized films of DB are investigated for mechanical, water vapor transmission...

The development of microneedles (MNs) assisted drug delivery technologies have been highly active for more than two decades. minimally invasive and self-administered MN technology bypasses many challenges associated with injectable systems, by delivering the therapeutic materials directly into dermal ocular space allowing release ingredient in a sustained or controlled manner. Different types M...

The rationale for sustained release oral levodopa preparations is to deliver levodopa in the areas of maximal intestinal absorption in a slow and predictable way, leading to stable plasma levodopa levels and brain dopamine levels, therefore resulting in a lengthened duration of action. Sinemet CR is the prototype of such preparations, with demonstrated efficacy in decreasing periods of akinesia...

Extended-release matrix tablets of diltiazem hydrochloride (DTZ) were prepared using waxy materials alone or in combination with Kollidon SR. Matrix waxy materials were carnauba wax (CW), bees wax (BW), cetyl alcohol (CA) and glyceryl monostearate (GMS). Dissolution studies were carried out by using a six stations USP XXII type 1 apparatus. The in vitro drug release study was done in 1000 ml ph...

Objective(s): Colorectal cancer (CRC) is a prevalent cancer worldwide. The present study aimed to synthesize and investigate the potential of wheat germ agglutinin (WGA) conjugated with polylactic-co-glycolic acid (PLGA) nanoparticles (NPs) incorporating 5-fluorouracil (5-FU). Materials and Methods: The NPs were investigated in terms of various characteristics, such as the particle size, ...

We report a multifunctional micromotor fabricated by the self-assembly technique using multifunctional materials, i.e. polymer single crystals and nanoparticles, as basic building blocks. Not only can this micromotor achieve autonomous and directed movement, it also possesses unprecedented functions, including enzymatic degradation-induced micromotor disassembly, sustained release and molecular...

the first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using peg 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. the second objective was to apply the modified solvent method for preparation of sustained release ...