BACKGROUND This study examines the biophysical and preclinical pulmonary activity of synthetic lung surfactants containing novel phospholipase-resistant phosphonolipids or synthetic glycerophospholipids combined with Super Mini-B (S-MB) DATK and/or SP-Css ion-lock 1 peptides that replicate the functional biophysics of surfactant proteins (SP)-B and SP-C. Phospholipase-resistant phosphonolipids ...

The efficacy of the surfactants SDS and CTAB in detaching P. fluorescens from glass surface was evaluated in a parallel plate flow chamber. This device enables "in situ" determinations of cells detachment following the application of surfactants under well controlled hydrodynamic conditions. The results showed that SDS was able to remove almost all adhering bacteria in a short period of time, w...

Possibilities of application of non-ionic surfactants of Rofam type as solubilizers for piroxicam poorly dissolved in water were assessed. Homologous series of Rofams containing oxyethylene segments from 3 to 18 were used in the study. Tablet formulation was made by wet granulation technique using these surfactants in order to improve drug dissolution properties. Influence of both quantity and ...

Modelling of the critical micelle concentrations (cmc) using the molecular connectivity indices was performed for a set of 21 cationic gemini surfactants with medium-length spacers. The obtained model contains only the second-order Kier and Hall molecular connectivity index. It is suggested that the index 2χ includes some information about flexibility. The obtained model was used to predict log...

Bioremediation processes are negatively affected by the low aqueous solubility of some contaminants; therefore their bioavailability may be enhanced by the addition of surfactants. These compounds are organic molecules that can be chemically and biologically produced. Surfactants contain both hydrophilic and hydrophobic groups, therefore reducing surface and interfacial tensions of immiscible f...

Anionic surfactants are commonly determined with the use of the methylene blue active substances (MBAS) standard method, which is time-consuming and labor-intensive. Therefore, new methods for determination of anionic surfactants are needed. In this study, the standard MBAS method for determination of anionic surfactants was modified and adjusted to work in a continuous flow system combined wit...

An achiral monomeric surfactant (sodium 10-undecenyl sulfate, SUS) and a chiral surfactant (sodium 10-undecenoyl L-leucinate, SUL) were synthesized and polymerized individually to form poly-SUS and poly-SUL. These surfactants were then copolymerized at various molar ratios to produce a variety of copolymerized surfactants (CoPSs), possessing both achiral (sulfate) and chiral (leucinate) head gr...